A systematic review and meta-analysis of CA VI, AMBN, and TUFT1 polymorphisms and dental caries risk

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dc.authoridHatipoglu, Omer/0000-0002-4628-8551
dc.authoridSadeghi, Masoud/0000-0002-3586-3012
dc.authoridTadakamadla, Santosh/0000-0003-2775-2897
dc.contributor.authorSharifi, Roohollah
dc.contributor.authorShayan, Alireza
dc.contributor.authorJamshidy, Ladan
dc.contributor.authorMozaffari, Hamid Reza
dc.contributor.authorHatipolu, Omer
dc.contributor.authorTadakamadla, Santosh Kumar
dc.contributor.authorSadeghi, Masoud
dc.date.accessioned2024-11-07T13:34:27Z
dc.date.available2024-11-07T13:34:27Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractDental caries is a multifactorial disease and the cause of caries has been studied for many years. Herein, a metaanalysis purposed to estimate the association between polymorphism of Carbonic anhydrase VI (CA VI), Ameloblastin (AMBN), and Toftelin (TUFT1) genes and dental caries susceptibility. Four databases of Cochrane Library, Web of Science, PubMed/Medline, and Scopus databases were searched comprehensively until February 13, 2020. The pooled analyses were implemented by Review Manager 5.3 software and publication bias analyzed by the Comprehensive Meta-Analysis version 2.0 software. Eight studies were included and analyzed in the metaanalysis. The pooled analyses illustrated that the CA VI rs2274328, CA VI rs2274333, CA VI rs2274327, AMBN rs4694075, AMBN rs34538475, TUFT1 rs4970957, and TUFT1 rs3790506 polymorphisms were not associated with the susceptibility to dental caries. The age group and ethnicity were not effective factors on the results of the polymorphisms. The sensitivity analyses confirmed the stability of the pooled results. In addition, there was no publication bias across the studies. The results of this meta-analysis suggested a lack of association between AMBN, TUFT1, and CA VI polymorphisms and susceptibility to dental caries.
dc.description.sponsorshipResearch Council of Kermanshah University of Medical Sciences [980703]
dc.description.sponsorshipThis study was funded by the Research Council of Kermanshah University of Medical Sciences (Grant Number: 980703) .
dc.identifier.doi10.1016/j.mgene.2021.100866
dc.identifier.issn2214-5400
dc.identifier.scopus2-s2.0-85100657997
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2021.100866
dc.identifier.urihttps://hdl.handle.net/11480/15976
dc.identifier.volume28
dc.identifier.wosWOS:000641584300017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMeta Gene
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectDental caries
dc.subjectTooth decay
dc.subjectCarbonic anhydrase
dc.subjectAmeloblastin
dc.subjectToftelin
dc.titleA systematic review and meta-analysis of CA VI, AMBN, and TUFT1 polymorphisms and dental caries risk
dc.typeReview Article

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