Response to chronic sustained hypoxia: increased cytosolic gelsolin and decreased plasma gelsolin levels

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dc.authoridKULOGLU, NURHAN/0000-0002-1199-2784
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.authoridBASARAN, KEMAL ERDEM/0000-0001-6035-9398
dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.authoridYAZICI, Cevat/0000-0003-0625-9542
dc.contributor.authorGunturk, Inayet
dc.contributor.authorKuloglu, Nurhan
dc.contributor.authorSeydel, Gonul Seyda
dc.contributor.authorYazici, Cevat
dc.contributor.authorBasaran, Kemal Erdem
dc.contributor.authorYakan, Birkan
dc.contributor.authorKarabulut, Derya
dc.date.accessioned2024-11-07T13:32:13Z
dc.date.available2024-11-07T13:32:13Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAn actin binding protein, gelsolin (GSN) has two isoforms, plasma (pGSN) and cytosolic (cGSN). Changes in pGSN and/or cGSN levels have been shown to be associated with the pathogenesis of several diseases. The aim of this study was to evaluate changes in intracellular and extracellular GSNlevels with HIF-1 in animals exposed to chronic sustained hypoxia (CSH), in addition to apoptosis and the cellular redox status. The rats in the Sham group were exposed to 21% O-2, and the rats in the hypoxia groups were exposed to 13 and 10% O-2, respectively. Plasma pGSN, HIF-1 alpha, Total Antioxidant Status (TAS) and Total Oxidant Status (TOS), and lung tissue pGSN, HIF-1 alpha, TAS, TOS, GSN levels, and apoptotic cell numbers were measured. HIF-1 alpha levels were found to increase significantly in the tissue, especially in the group with severe hypoxia, both in biochemical and histological examinations. pGSN levels were also significantly decreased in both plasma and tissue. Significant increases in tissue were observed in cGSN. It was observed that while the antioxidant activity was dominant in the tissue, the oxidant activity was dominant in the plasma. In particular, the response to hypoxia regulated by HIF-1 is very important for cellular survival. The results of this study showed that the increase in cGSN and TAS levels in the lung tissue together with HIF-1 alpha can be considered as the activation of mechanisms for cellular protection.
dc.description.sponsorshipResearch Fund of Nigde Omer Halisdemir University [SAT 2022/6-BAGEP]
dc.description.sponsorshipThis study was supported by the Research Fund of Nigde Omer Halisdemir University (Grant No. SAT 2022/6-BAGEP).
dc.identifier.doi10.1007/s10735-024-10248-8
dc.identifier.endpage1019
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue5
dc.identifier.pmid39172327
dc.identifier.scopus2-s2.0-85201826942
dc.identifier.scopusqualityQ2
dc.identifier.startpage1009
dc.identifier.urihttps://doi.org/10.1007/s10735-024-10248-8
dc.identifier.urihttps://hdl.handle.net/11480/15280
dc.identifier.volume55
dc.identifier.wosWOS:001296487000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectChronic sustained hypoxia
dc.subjectPlasma gelsolin
dc.subjectCytosolic gelsolin
dc.subjectHIF-1
dc.subjectOxidative stress
dc.subjectApoptosis
dc.titleResponse to chronic sustained hypoxia: increased cytosolic gelsolin and decreased plasma gelsolin levels
dc.typeArticle

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