Nuclear anomalies in the buccal cells of calcite factory workers

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dc.contributor.authorDiler S.B.
dc.contributor.authorErgene S.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2010
dc.departmentNiğde ÖHÜ
dc.description.abstractThe micronucleus (MN) assay on exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. To determine the genotoxic effects of calcite dust that forms during processing, MN assay was carried out in exfoliated buccal cells of 50 (25 smokers and 25 non-smokers) calcite factory workers and 50 (25 smokers and 25 non-smokers) age- and sex-matched control subjects. Frequencies of nuclear abnormalities (NA) other than micronuclei, such as binucleates, karyorrhexis, karyolysis and 'broken eggs', were also evaluated. Micronuclei and the other aforementioned anomalies were analysed by two way analysis of covariance. The linear correlations between the types of micronucleus and nuclear abnormalities were determined by Spearman's Rho. There was a positive correlation between micronuclei and other types of nuclear abnormalities in accordance with the Spearman's Rho test. Results showed statistically significant difference between calcite fabric workers and control groups. MN and NA frequencies in calcite fabric workers were significantly higher than those in control groups (p < 0.05). The results of this study indicate that calcite fabric workers are under risk of significant cytogenetic damage. © 2010, Sociedade Brasileira de Genética.
dc.identifier.doi10.1590/S1415-47572010005000021
dc.identifier.endpage378
dc.identifier.issn1415-4757
dc.identifier.issue2
dc.identifier.pmid21637497
dc.identifier.scopus2-s2.0-77954368890
dc.identifier.scopusqualityQ3
dc.identifier.startpage374
dc.identifier.urihttps://dx.doi.org/10.1590/S1415-47572010005000021
dc.identifier.urihttps://hdl.handle.net/11480/1049
dc.identifier.volume33
dc.identifier.wosWOS:000278958700028
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherBrazilian Journal of Genetics
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCalcite
dc.subjectExfoliated buccal cells
dc.subjectGenotoxicity
dc.subjectMicronucleus (MN)
dc.titleNuclear anomalies in the buccal cells of calcite factory workers
dc.typeArticle

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