Cytogenetic Biomonitoring of Carpet Fabric Workers Using Micronucleus Frequency, Nuclear Changes, and the Calculation of Risk Assessment by Repair Index in Exfoliated Mucosa Cells

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dc.authorid0000-0002-0127-3639
dc.contributor.authorDiler, Songul Budak
dc.contributor.authorCelik, Ayla
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2011
dc.departmentNiğde ÖHÜ
dc.description.abstractThe micronucleus (MN) assay in exfoliated buccal cells is a minimally invasive method for monitoring genetic damage in human populations and is used as an indicator of genotoxic exposition, as it is associated with chromosome aberrations. In this study, we evaluated MN frequencies and other nuclear changes (NCs), such as karyorrhexis (KR), karyolysis (KL), broken egg (BE), and binucleus in buccal mucosa cells of 50 carpet fabric workers (25 smokers and 25 nonsmokers) and 50 healthy control subjects (25 smokers and 25 nonsmokers). Microscopic observation of 2000 cells per individual was performed in both workers and control subjects. In both the control group and the exposed group, for each person a repair index (RI) was calculated via the following formula: (KR+KL)/(BE+MN). The results showed a statistically significant increase in the frequency of MN in buccal epithelial cells of exposed group compared with control group. There is a significant difference between worker and control groups (p<0.001) for RI. We believe that the calculation of RI values, in addition to nuclear changes, presents a new approach in risk assessment in relation to occupational exposure.
dc.identifier.doi10.1089/dna.2011.1216
dc.identifier.endpage827
dc.identifier.issn1044-5498
dc.identifier.issn1557-7430
dc.identifier.issue10
dc.identifier.pmid21495858
dc.identifier.scopus2-s2.0-80053518250
dc.identifier.scopusqualityQ2
dc.identifier.startpage821
dc.identifier.urihttps://dx.doi.org/10.1089/dna.2011.1216
dc.identifier.urihttps://hdl.handle.net/11480/4683
dc.identifier.volume30
dc.identifier.wosWOS:000295396900009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherMARY ANN LIEBERT, INC
dc.relation.ispartofDNA AND CELL BIOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleCytogenetic Biomonitoring of Carpet Fabric Workers Using Micronucleus Frequency, Nuclear Changes, and the Calculation of Risk Assessment by Repair Index in Exfoliated Mucosa Cells
dc.typeArticle

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