Importance of Histopathological Grading for Treatment Selection in Malignant Mesothelioma

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dc.authoridTurk, Ilteris/0000-0001-6385-4722
dc.authoridDemirag, Funda/0000-0003-4790-8369
dc.authoridCETIN, MEHMET/0000-0001-5471-2239
dc.authoridaydogdu, koray/0000-0003-1379-2855
dc.authoridGulhan, Selim Sakir Erkmen/0000-0002-1143-9655
dc.authoridfindik, gokturk/0000-0002-8861-7608
dc.contributor.authorTurk, Ilteris
dc.contributor.authorFindik, Gokturk
dc.contributor.authorcetin, Mehmet
dc.contributor.authorBicakcioglu, Pinar
dc.contributor.authorGulhan, Selim Sakir Erkmen
dc.contributor.authorAydogdu, Koray
dc.contributor.authorYilmaz, Ulku
dc.date.accessioned2024-11-07T13:25:09Z
dc.date.available2024-11-07T13:25:09Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground Complexities in TNM staging in epithelioid malignant pleural mesothelioma (MPM) may lead to errors in treatment selection, leading to major surgical interventions in patients with low survival expectations.Methods Sixty-nine stage I epithelioid MPM patients, including 27 patients treated with pleurectomy/decortication (P/D) and multimodal therapy (MMT) (the P/D [MMT] group), and 42 patients treated with chemotherapy or chemoradiotherapy (the CRT group), were included in the study. After an initial evaluation of overall survival, all patients were grouped in terms of histopathological parameters and treatment types, and then, a secondary survival evaluation was performed for the groups.Results Forty-one patients were male, the mean age was 61.8 years. The median survival time was 26 months in the P/D (MMT) group, and 19.6 months in the CRT group, but the difference was not statistically significant. After grouping according to pathological criteria, a median survival time of 32.4 +/- 2.9 months in the P/D (MMT) group and 21.9 +/- 13.2 months in the CRT group was obtained among patients with histopathological low-grade tumors. Among patients with high-grade tumors, the median survival time was 18.3 +/- 2.6 months in the P/D (MMT) group and 17 +/- 4.4 months in the CRT group. Among patients with low-grade tumors, the P/D (MMT) group had longer survival. Median survival times were similar among patients with high-grade tumors.Conclusion In epithelioid MPM, histopathological grading by video-assisted thoracic surgery pleural biopsy can prove accurate in selecting patients for P/D and MMT.
dc.identifier.doi10.1055/s-0043-1761209
dc.identifier.endpage503
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue6
dc.identifier.pmid36736368
dc.identifier.scopus2-s2.0-85169848809
dc.identifier.scopusqualityQ2
dc.identifier.startpage497
dc.identifier.urihttps://doi.org/10.1055/s-0043-1761209
dc.identifier.urihttps://hdl.handle.net/11480/14541
dc.identifier.volume71
dc.identifier.wosWOS:000925910100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofThoracic and Cardiovascular Surgeon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectmalignant pleural mesothelioma
dc.subjecthistopathological grading
dc.subjectnuclear grading system
dc.subjectpleuretomy
dc.subjectdecortication
dc.titleImportance of Histopathological Grading for Treatment Selection in Malignant Mesothelioma
dc.typeArticle

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