Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

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dc.contributor.authorRiaz A.
dc.contributor.authorRasul A.
dc.contributor.authorHussain G.
dc.contributor.authorZahoor M.K.
dc.contributor.authorJabeen F.
dc.contributor.authorSubhani Z.
dc.contributor.authorSelamoglu Z.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractNatural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-B, TNF-?, and TGF-ß1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1?, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLC?1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IB?, PI3K, and PKCß2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1ß, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-?). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates. © 2018 Ammara Riaz et al.
dc.identifier.doi10.1155/2018/9794625
dc.identifier.issn1687-6334
dc.identifier.pmid29853868
dc.identifier.scopus2-s2.0-85048162061
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://dx.doi.org/10.1155/2018/9794625
dc.identifier.urihttps://hdl.handle.net/11480/1750
dc.identifier.volume2018
dc.identifier.wosWOS:000432202000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherHindawi Limited
dc.relation.ispartofAdvances in Pharmacological Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAstragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
dc.typeReview Article

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