Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?

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dc.contributor.authorErdemli M.E.
dc.contributor.authorGul M.
dc.contributor.authorAltinoz E.
dc.contributor.authorAksungur Z.
dc.contributor.authorGul S.
dc.contributor.authorBag H.G.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractObjective(s): To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P?0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman’s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P?0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Conclusion: At this dose and time interval, against a highly toxic chemical such as CCl4, crocin was able to suppress oxidative stress by playing a protective role in the kidney tissue. © 2018, Mashhad University of Medical Sciences. All rights reserved.
dc.identifier.doi10.22038/ijbms.2018.26101.6412
dc.identifier.endpage387
dc.identifier.issn2008-3866
dc.identifier.issue4
dc.identifier.pmid29796221
dc.identifier.scopus2-s2.0-85043767006
dc.identifier.scopusqualityQ2
dc.identifier.startpage382
dc.identifier.urihttps://dx.doi.org/10.22038/ijbms.2018.26101.6412
dc.identifier.urihttps://hdl.handle.net/11480/1677
dc.identifier.volume21
dc.identifier.wosWOS:000433358700006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbon tetrachloride
dc.subjectCrocin
dc.subjectKidney
dc.subjectOxidative stress
dc.subjectRat
dc.titleCan crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?
dc.typeArticle

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