EVALUATION OF OXIDATIVE STRESS, 3-NITROTYROSINE, AND HMGB-1 LEVELS IN PATIENTS WITH WET TYPE AGE-RELATED MACULAR DEGENERATION

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dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.authoridSari, Ismail/0000-0003-3732-2102
dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.contributor.authorZor, Kursad Ramazan
dc.contributor.authorSari, Ismail
dc.contributor.authorBicer, Gamze Yildirim
dc.contributor.authorGunturk, Inayet
dc.contributor.authorKucuk, Erkut
dc.contributor.authorErsan, Serpil
dc.contributor.authorSeydel, Gonul Seyda
dc.date.accessioned2024-11-07T13:25:04Z
dc.date.available2024-11-07T13:25:04Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: This study aims to compare serum HMGB-1, 3-nitrotyrosine (3-NT), TAS, TOS, and OSI levels in Wettype Age-Related Macular Degeneration (wAMD) patients and healthy controls to determine the correlation of these parameters with each other. Methods: Thirty patients with Wet-type Age-Related Macular Degeneration (wAMD) and 27 healthy adults, as controls were enrolled in the study. We determined the TAS and TOS levels in serum samples of both groups using commercial kits on a microplate reader. Serum HMGB-1 and 3-NT levels were measured with the enzyme-linked immunosorbent assay method. Results: HMGB-1 levels were significantly higher in the patient group (137.51 pg/mL, p=0.001), while there was no difference between the two groups in serum 3-NT levels (p = 0.428). A statistically significant difference found in the levels of TOS and OSI (p = 0.001 and p = 0.045, respectively) between the patients and controls, however, no significant difference was observed between the groups in terms of TAS levels (p = 0.228). Conclusions: Oxidative stress and HMGB-1 levels were increased in wAMD patients and enhanced oxidative stress may be associated with increased tissue necrosis and inflammation. Thus administration of antioxidant treatment in addition to routine therapy should be considered in wAMD.
dc.identifier.doi10.5937/jomb0-32189
dc.identifier.endpage281
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue3
dc.identifier.pmid36042902
dc.identifier.scopus2-s2.0-85144680259
dc.identifier.scopusqualityQ3
dc.identifier.startpage275
dc.identifier.urihttps://doi.org/10.5937/jomb0-32189
dc.identifier.urihttps://hdl.handle.net/11480/14467
dc.identifier.volume41
dc.identifier.wosWOS:000836336400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectHMGB-1
dc.subject3-Nitrotyrosine
dc.subjectTAS
dc.subjectTOS
dc.subjectOSI
dc.subjectwet type AMD
dc.titleEVALUATION OF OXIDATIVE STRESS, 3-NITROTYROSINE, AND HMGB-1 LEVELS IN PATIENTS WITH WET TYPE AGE-RELATED MACULAR DEGENERATION
dc.title.alternativePROCENA OKSIDATIVNOG STRESA, NIVOA 3-NITROTIROZINA I HMBG-1 KOD PACIJENATA SA VLA?NOM VRSTOM MAKULARNE DEGENERACIJE
dc.typeArticle

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