Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24- cancer stem cells in MCF-7 cell populations

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dc.contributor.authorŞener L.T.
dc.contributor.authorGüven C.
dc.contributor.authorŞener A.
dc.contributor.authorÇinar S.A.
dc.contributor.authorSolakoğlu S.
dc.contributor.authorAlbeniz I.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2018
dc.departmentNiğde ÖHÜ
dc.description.abstractBreast cancer is the most common type of cancer in females and the second most common cause of cancer mortality after lung cancer. Cancer stem cells represent a novel approach to target cancer and reduce cancer recurrence and metastasis. Many patients with breast cancer continue to smoke after receiving their diagnosis. Nicotine is a key factor in tobacco addiction and also changes some cellular functions, such as activation of mitogenic pathways, angiogenesis and cell proliferation. In the present study, the impact of nicotine was assessed in a population of MCF-7 human breast cancer cells. Cluster of differentiation (CD)44+CD24- cancer stem cell population of MCF-7 cells were evaluated using flow cytometry and scanning electron microscopy. Chemoresistance effects of nicotine were demonstrated in these cells. These findings demonstrated harmful effects of nicotine following metastasis of cancer, owing to the chemoresistance produced through uninterrupted smoking, which may impact the effectiveness of treatment. © 2018, Spandidos Publications. All rights reserved.
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit
dc.description.sponsorshipThe present study was supported by the Scientific Research Projects Coordination Unit of Istanbul University (project no. 25945).
dc.identifier.doi10.3892/etm.2018.6149
dc.identifier.endpage28
dc.identifier.issn1792-0981
dc.identifier.issue1
dc.identifier.startpage21
dc.identifier.urihttps://dx.doi.org/10.3892/etm.2018.6149
dc.identifier.urihttps://hdl.handle.net/11480/1636
dc.identifier.volume16
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSpandidos Publications
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast cancer
dc.subjectCancer stem cells
dc.subjectChemoresistance
dc.subjectNicotine
dc.titleNicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44+CD24- cancer stem cells in MCF-7 cell populations
dc.typeArticle

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