Investigation of distribution of GSK-3ß signal pathway by age groups in cases of ulcerative colitis

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dc.authoridOZBEY, CANER/0000-0002-5001-5150
dc.contributor.authorOzbey, Caner
dc.contributor.authorAydemir, Isil
dc.date.accessioned2024-11-07T13:24:09Z
dc.date.available2024-11-07T13:24:09Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractUlcerative colitis (UC), one of the inflammatory bowel diseases, has been reported to increase in recent years. Although the exact cause is unknown, disruptions in the molecular pathways are thought to trigger UC. We aimed to examine the distributions of glycogen synthase kinase-3beta (GSK-3 ss), nuclear factor-kappa B (NF-kappa B) and wingless/int-1 (Wnt-1) in different age groups diagnosed with UC. Patients diagnosed with UC were divided into four groups according to their ages: Group 1, aged 18-30 (n=20); Group 2, aged 31-45 (n=20); Group 3, aged 46-60 (n=20); Group 4, aged 61-75 ( n=20). Tissue sections were histochemically stained to examine the parameters of epithelial cell height, length of crypt, thickness of muscularis mucosa and extent of submucosal fibrosis. The immunohistochemistry assay was performed using cell survival and for GSK-3 ss, NF-.B and Wnt-1 cell growth markers. Immunoreactivities were evaluated using H-score and analyzed using the one-way analysis of variance (ANOVA) test for statistics. It was detected a decrease in the histopathological parameters whereas the immunoreactivities of GSK-3 ss, NF-kappa B and Wnt-1 were increased with increasing age. The levels of GSK-3 ss immunoreactivity were similar in both epithelium and submucosa in all groups. NF-.B immunoreactivity was higher in submucosa of Groups 1, 2 and 3, while Wnt-1 was enhanced in Groups 1 and 3. The results of histopathology showed that the integrity of the epithelial tissue in the colon deteriorated with increasing age. The expressions of GSK-3 ss, NF-kappa B and Wnt-1 were detected in all age groups. We thought that there was a synergistic activation between these three markers. Nevertheless, studies are needed to investigate this molecular pathway.
dc.identifier.doi10.47162/RJME.64.1.07
dc.identifier.endpage63
dc.identifier.issn1220-0522
dc.identifier.issn2066-8279
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85158041682
dc.identifier.scopusqualityQ3
dc.identifier.startpage57
dc.identifier.urihttps://doi.org/10.47162/RJME.64.1.07
dc.identifier.urihttps://hdl.handle.net/11480/13950
dc.identifier.volume64
dc.identifier.wosWOS:001062814000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofRomanian Journal of Morphology and Embryology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectinflammatory bowel diseases
dc.subjectGSK-3 ss
dc.subjectNF-kappa B
dc.subjectulcerative colitis
dc.subjectWnt-1
dc.titleInvestigation of distribution of GSK-3ß signal pathway by age groups in cases of ulcerative colitis
dc.typeArticle

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