Is the course of COVID-19 associated with tuberculin skin test diameter? A retrospective study

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dc.authoridYaksi Sahin, Nese/0000-0002-6175-2359
dc.authoridARSLAN GULEN, TUGBA/0000-0001-5706-9824
dc.authoridKayabas, Uner/0000-0002-5323-0796
dc.contributor.authorGulen, Tugba Arslan
dc.contributor.authorBayraktar, Muhammet
dc.contributor.authorYaksi, Nese
dc.contributor.authorKayabas, Uner
dc.date.accessioned2024-11-07T13:25:14Z
dc.date.available2024-11-07T13:25:14Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe pathogenesis of coronavirus disease 2019 (COVID-19) is still not fully understood. As severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has a similar pathogenetic pathway to Mycobacterium tuberculosis, it has been reported that there may be a relationship between Bacille Calmette-Guerin (BCG) vaccination rate and COVID-19 severity. This study investigated the relationship between tuberculin skin test (TST) induration diameter and the clinical course of COVID-19. Of 1963 adult patients who underwent TST, 76 patients with SARS-COV-2 infection confirmed by RT-PCR analysis of respiratory tract samples were included in the study. Relationships between COVID-19 clinical severity and TST positivity, induration size, and other clinical parameters were analyzed. Of the 76 patients, TST results were negative for 53 patients (69.7%) and positive for 23 patients (30.3%). COVID-19 severity was mild in 47 patients (61.8%), moderate in 22 patients (28.9%), and severe in seven patients (9.3%). All TST-positive patients had mild disease. Patients with mild disease had a significantly higher TST positivity rate (p < 0.001) and larger induration diameter (p < 0.001). The area under the receiver operating characteristic (ROC) curve of TST induration size for the differentiation of mild with moderate and severe disease was 0.768 (p < 0.001). The maximum Youden J index value was 0.522 at an induration diameter of 6.5 mm, which had a sensitivity of 66.0% and specificity of 86.2%. COVID-19 patients with positive TST showed a significantly higher rate of mild disease than those with negative TST. TST positivity is favorably associated with the course of COVID-19.
dc.identifier.doi10.1002/jmv.27414
dc.identifier.endpage1026
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue3
dc.identifier.pmid34676582
dc.identifier.scopus2-s2.0-85118225427
dc.identifier.scopusqualityQ1
dc.identifier.startpage1020
dc.identifier.urihttps://doi.org/10.1002/jmv.27414
dc.identifier.urihttps://hdl.handle.net/11480/14578
dc.identifier.volume94
dc.identifier.wosWOS:000712288200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectMycobacterium tuberculosis
dc.subjectpathogenesis
dc.subjectprognosis
dc.subjectSARS-COV-2
dc.subjecttuberculin skin test
dc.titleIs the course of COVID-19 associated with tuberculin skin test diameter? A retrospective study
dc.typeArticle

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