COVID-19-associated pulmonary aspergillosis (CAPA): identification of Aspergillus species and determination of antifungal susceptibility profiles

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dc.authoridIBRAHIM, Bashar/0000-0003-3086-0995
dc.authoridBozok, Taylan/0000-0002-7094-4838
dc.contributor.authorOzturk, Ali
dc.contributor.authorBozok, Taylan
dc.contributor.authorErdogan, Merve
dc.contributor.authorIbrahim, Bashar M. S.
dc.contributor.authorBozok, Tugce Simsek
dc.date.accessioned2024-11-07T13:35:03Z
dc.date.available2024-11-07T13:35:03Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAmong the co-infectious agents in COVID-19 patients, Aspergillus species cause invasive pulmonary aspergillosis (IPA). IPA is difficult to diagnose and is associated with high morbidity and mortality. This study is aimed at identifying Aspergillus spp. from sputum and tracheal aspirate (TA) samples of COVID-19 patients and at determining their antifungal susceptibility profiles. A total of 50 patients with COVID-19 hospitalized in their intensive care units (ICU) were included in the study. Identification of Aspergillus isolates was performed by phenotypic and molecular methods. ECMM/ISHAM consensus criteria were used for IPA case definitions. The antifungal susceptibility profiles of isolates were determined by the microdilution method. Aspergillus spp. was detected in 35 (70%) of the clinical samples. Among the Aspergillus spp., 20 (57.1%) A. fumigatus, six (17.1%) A. flavus, four (11.4%) A. niger, three (8.6%) A. terreus, and two (5.7%) A. welwitschiae were identified. In general, Aspergillus isolates were susceptible to the tested antifungal agents. In the study, nine patients were diagnosed with possible IPA, 11 patients were diagnosed with probable IPA, and 15 patients were diagnosed with Aspergillus colonization according to the used algorithms. Serum galactomannan antigen positivity was found in 11 of the patients diagnosed with IPA. Our results provide data on the incidence of IPA, identification of Aspergillus spp., and its susceptibility profiles in critically ill COVID-19 patients. Prospective studies are needed for a faster diagnosis or antifungal prophylaxis to manage the poor prognosis of IPA and reduce the risk of mortality.
dc.identifier.doi10.1007/s12223-023-01069-5
dc.identifier.endpage959
dc.identifier.issn0015-5632
dc.identifier.issn1874-9356
dc.identifier.issue6
dc.identifier.pmid37294497
dc.identifier.scopus2-s2.0-85161391404
dc.identifier.scopusqualityQ3
dc.identifier.startpage951
dc.identifier.urihttps://doi.org/10.1007/s12223-023-01069-5
dc.identifier.urihttps://hdl.handle.net/11480/16308
dc.identifier.volume68
dc.identifier.wosWOS:001003910800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofFolia Microbiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAspergillus spp
dc.subjectInvasive pulmonary aspergillosis
dc.subjectCOVID-19
dc.subjectAntifungal susceptibility
dc.subjectSARS-CoV-2
dc.titleCOVID-19-associated pulmonary aspergillosis (CAPA): identification of Aspergillus species and determination of antifungal susceptibility profiles
dc.typeArticle

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