Prevalence of Hemoglobinopathies in Premarital Screening in the Province of Nigde, Turkey

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dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.contributor.authorSeydel, Gonul Seyda
dc.contributor.authorAyan, Durmus
dc.contributor.authorBalci, Tevfik
dc.contributor.authorBayraktar, Muhammet
dc.contributor.authorGunturk, Inayet
dc.date.accessioned2024-11-07T13:25:15Z
dc.date.available2024-11-07T13:25:15Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractHemoglobinopathies are one of the most widespread hereditary disorders in Turkey. The present study aimed to determine the prevalence of hemoglobinopathies in the Nigde province of Turkey. This study was conducted with 2013 individuals who applied for the premarital screening, between January 2019 and December 2021. The complete blood count was measured by an automated hematology analyzer. The types of hemoglobin were determined by high-performance liquid chromatography. A total of 2013 individuals including 951 (47.2%) females and 1062 (52.8%) males, were screened within the premarital screening program, and 67 (3.3%) of them were migrants. 53 out of 2013 (2.63%) individuals were identified as beta thalassemia carriers, and five of them were migrants including two from Afghanistan, two from Iran, and one from Georgia. HbC was observed in two cases, a couple from Syria (0.1%), HbD in two cases (0.1%), HbE in one case from Thailand (0.05%), HbS-beta-thalassemia in one case (0.05%), delta-beta thalassemia in one case (0.05%), and unidentified structural variant in one case (0.05%). Moreover, 183 individuals (9.1%) were considered to have iron deficiency, alpha-thalassemia, or silent beta-thalassemia carrier. These results indicate that the province of Nigde is a relatively risky region regarding hemoglobinopathies. Geographic location and immigrant population may have slightly affected the local prevalence of hemoglobinopathies and could be taken into consideration to ensure the effective implementation of the hemoglobinopathy prevention program.
dc.identifier.doi10.1080/03630269.2023.2206971
dc.identifier.endpage41
dc.identifier.issn0363-0269
dc.identifier.issn1532-432X
dc.identifier.issue2
dc.identifier.pmid37184118
dc.identifier.scopus2-s2.0-85159305495
dc.identifier.scopusqualityQ3
dc.identifier.startpage36
dc.identifier.urihttps://doi.org/10.1080/03630269.2023.2206971
dc.identifier.urihttps://hdl.handle.net/11480/14587
dc.identifier.volume47
dc.identifier.wosWOS:000988935100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofHemoglobin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectHemoglobinopathies
dc.subjectthalassemia
dc.subjectpremarital screening
dc.subjectTurkey
dc.subjectmigrants
dc.titlePrevalence of Hemoglobinopathies in Premarital Screening in the Province of Nigde, Turkey
dc.typeArticle

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