Experimental and computational assessment of Antiparkinson Medication effects on meiofauna: Case study of Benserazide and Trihexyphenidyl

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dc.contributor.authorIshak, Sahar
dc.contributor.authorAllouche, Mohamed
dc.contributor.authorAlotaibi, Ghadah S.
dc.contributor.authorAlwthery, Nada S.
dc.contributor.authorAl-Subaie, Raghad A.
dc.contributor.authorAl-Hoshani, Nawal
dc.contributor.authorPlavan, Oana-Alexandra
dc.date.accessioned2024-11-07T13:35:27Z
dc.date.available2024-11-07T13:35:27Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractTwo concentrations (6.25 and 1.25 mg/L) were used for two Parkinson's disease medications, Benserazide, and Trihexyphenidyl, to test their effects on the meiobenthic nematofauna. It is predicted that these highly hydrosoluble drugs will end up in marine environments. The results showed that both medications when added alone, induced (i) important changes in the numbers and (ii) taxonomic composition. The impact of Benserazide and Trihexyphenidyl was also reflected in the (iii) functional traits of nematofauna, with the most affected categories following exposure being the trophic group 1B, the clavate tails, the circular amphids, the c-p2 life history, and the body length of 1-2 mm. These results were supported by the molecular interactions of the studied drugs with both GLD-3 and SDP proteins of Caenorhabditis elegans. (iv) The mixtures of both drugs did not show any changes in the nematode communities, suggesting that no synergistic or antagonistic interactions exist between them.
dc.description.sponsorshipDeanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) [IMSIU-RP23071]
dc.description.sponsorshipThis work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) (grant number IMSIU-RP23071) .
dc.identifier.doi10.1016/j.marpolbul.2024.116668
dc.identifier.issn0025-326X
dc.identifier.issn1879-3363
dc.identifier.pmid38972217
dc.identifier.scopus2-s2.0-85197616354
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.marpolbul.2024.116668
dc.identifier.urihttps://hdl.handle.net/11480/16521
dc.identifier.volume205
dc.identifier.wosWOS:001267617600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofMarine Pollution Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectBenserazide
dc.subjectTrihexyphenidyl
dc.subjectMeiobenthic nematodes
dc.subjectTaxon/functional traits
dc.subjectComputational analyses
dc.titleExperimental and computational assessment of Antiparkinson Medication effects on meiofauna: Case study of Benserazide and Trihexyphenidyl
dc.typeArticle

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