Alteration of butyrylcholinesterase level in cholelithiasis patients after laparoscopic cholecystectomy: Do butyrylcholinesterase levels affect lipid metabolism?

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dc.authoridayan, durmus/0000-0003-2615-8474
dc.contributor.authorAyan, Durmus
dc.contributor.authorBolat, Haci
dc.contributor.authorOzmen, Esma
dc.contributor.authorSari, Ismail
dc.date.accessioned2024-11-07T13:25:17Z
dc.date.available2024-11-07T13:25:17Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAim: Cholelithiasis (gallbladder stone) is a disease with a high incidence worldwide. The disease is multifactorial and various factors such as gender, age, obesity and use of oral contraceptives are held responsible for the development of the disease. In addition, lipid disorder is observed in more than 50% of patients with cholelithiasis. Laparoscopic cholecystectomy (LC) is one of the most frequently used surgical methods in the treatment of cholelithiasis, and there are data indicating that lipid profile changes and metabolic syndrome (MetS) develop after the operation. In this study, we aimed to investigate whether there is a change in lipid profile and Butyrylcholinesterase (BChE) activity, which affects lipid metabolism, in cholelithiasis patients after LC. Material and Methods: In our study, 31 patients (obese and non-obese) who applied to the general surgery clinic of Nigde Omer Halisdemir University Training and Research Hospital were included. Blood samples were taken from the patients before LC and 6 months after the operation, and the lipid levels and BChE enzyme activity were examined using spectrophotometric method. Results: According to the results, it was determined that the total cholesterol (p=0.015) and LDL (p=0.010) levels significantly decreased after LC, while no significant difference was found in the other parameters examined (p>0.05). In addition, it was observed that there was no significant correlation between the lipid profile examined both before and after LC and BChE activity level. Discussion: According to the data obtained, the significant decrease in LDL and total cholesterol after LC indicates that this operation causes a positive change at least within a period of 6 months in the lipid profile of patients.
dc.identifier.doi10.4328/ACAM.20655
dc.identifier.endpage1102
dc.identifier.issn2667-663X
dc.identifier.issue10
dc.identifier.startpage1098
dc.identifier.urihttps://doi.org/10.4328/ACAM.20655
dc.identifier.urihttps://hdl.handle.net/11480/14620
dc.identifier.volume12
dc.identifier.wosWOS:000732393900004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectButyrylcholinesterase
dc.subjectLaparoscopic Cholecystectomy
dc.subjectLipid Metabolism
dc.subjectCholelithiasis
dc.subjectLipid Profile
dc.titleAlteration of butyrylcholinesterase level in cholelithiasis patients after laparoscopic cholecystectomy: Do butyrylcholinesterase levels affect lipid metabolism?
dc.typeArticle

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