Association of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation

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dc.contributor.authorAltintas O.
dc.contributor.authorTasal A.
dc.contributor.authorNiftaliyev E.
dc.contributor.authorKucukdagli O.T.
dc.contributor.authorAsil T.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2016
dc.departmentNiğde ÖHÜ
dc.description.abstractObjectives: In this study, we aimed to evaluate whether the inflammation as measured by increased platelet to lymphocyte ratio (PLR) predispose to silent infarcts in patients with paroxysmal atrial fibrillation (PAF). Methods: The present study investigated a total of 48 new diagnosed patients with PAF who had no signs of stroke. PLR, which was calculated as the ratio of the platelet count to the lymphocyte count, C-reactive protein and erythrocyte sedimentation rate were measured due to evaluate inflammatory state. Magnetic resonance imaging (MRI) was performed to evaluate the presence of silent brain infarcts (SBIs) in patients. We calculated CHA2DS2–VASc scores for stratifying the stroke risk of patients. Results: Among our study population, the mean age was 56.40 ± 8.99; 36 patients were female. The leading vascular risk factor was hypertension (45.8%). SBI was determined in 16 patients (33.3%) on MRI. It was found that a higher PLR is significantly associated with the presence of SBIs in patients with PAF (P = .001). High PLR group showed silent lesions predominantly multiple, greater than 5 mm, bilateral and in the subcortical region; though no statistically significant differences were found in each lesion areas (P = .214; P = .509; P = .746; P = .059, respectively). Of 16 patients who showed SBI, 1 (6.3%) patient had CHA2DS2–Vasc scores of 0; 7 (43.8%) patients had CHA2DS2–Vasc scores of 1; 6 (37.5%) patients had CHA2DS2 -Vasc scores of 2 and 2 (12.5%) patients had CHA2DS2–Vasc scores of 3. We did not find any significant relationship between CHA2DS2–Vasc scores and presence of SBI in the study patients (P = .850). Discussion: High PLR might be a factor to induce inflammatory process on SBIs even with low CHA2DS2–VASc scores. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.doi10.1080/01616412.2016.1210357
dc.identifier.endpage758
dc.identifier.issn0161-6412
dc.identifier.issue9
dc.identifier.pmid27456433
dc.identifier.startpage753
dc.identifier.urihttps://dx.doi.org/10.1080/01616412.2016.1210357
dc.identifier.urihttps://hdl.handle.net/11480/1823
dc.identifier.volume38
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardioemboli
dc.subjectParoxysmal atrial fibrillation
dc.subjectPlatelet-to-lymphocyte ratio
dc.subjectSilent brain infarct
dc.subjectStroke prevention
dc.titleAssociation of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation
dc.typeArticle

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