Elevated serum S-100B levels in children with temporal lobe epilepsy

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dc.contributor.authorCalik M.
dc.contributor.authorAbuhandan M.
dc.contributor.authorSonmezler A.
dc.contributor.authorKandemir H.
dc.contributor.authorOz I.
dc.contributor.authorTaskin A.
dc.contributor.authorIscan A.
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractPurpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy. Methods: This case-controlled cross-sectional study was performed at the Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, in Turkey. Serum S-100B protein levels were studied in 19 (12 females, 7 males) children with temporal lobe epilepsy and in 25 (15 females, 10 males) healthy control subjects. Serum samples were collected within 30 min after a complex partial seizure, and serum S-100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of protein (ECLIA kit, Roche® Diagnostics, Germany). Results: The mean serum concentration of S-100B protein was 0.12 ± 0.02 µg/L in the temporal lobe epilepsy group and 0.07 ± 0.01 µg/L in the control group. The patients showed significantly elevated S-100B protein levels compared with healthy controls (P < 0.001). Conclusion: Our data suggest that increased S-100B protein levels in the serum might reflect neuronal damage in the brains of children with temporal lobe epilepsy. These results do confirm the previous findings of elevated S-100B protein levels in adult patients with temporal lobe epilepsy. © 2012 British Epilepsy Association.
dc.identifier.doi10.1016/j.seizure.2012.10.012
dc.identifier.endpage102
dc.identifier.issn1059-1311
dc.identifier.issue2
dc.identifier.pmid23146618
dc.identifier.startpage99
dc.identifier.urihttps://dx.doi.org/10.1016/j.seizure.2012.10.012
dc.identifier.urihttps://hdl.handle.net/11480/840
dc.identifier.volume22
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.relation.ispartofSeizure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemical marker
dc.subjectChildren
dc.subjectS-100B level
dc.subjectTemporal lobe epilepsy
dc.titleElevated serum S-100B levels in children with temporal lobe epilepsy
dc.typeArticle

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