A comprehensive analysis of the angiogenesis-related genes in glioblastoma multiforme vs. brain lower grade glioma

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dc.authoridBiterge Sut, Burcu/0000-0001-5756-5756
dc.contributor.authorSut, Burcu Biterge
dc.date.accessioned2024-11-07T13:25:14Z
dc.date.available2024-11-07T13:25:14Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBrain tumors are one of the most common causes of cancer-related deaths around the world. Angiogenesis is critical in high-grade malignant gliomas, such as glioblastoma multiforme. Objective: The aim of this study is to comparatively analyze the angiogenesis-related genes, namely VEGFA, VEGFB, KDR, CXCL8, CXCR1 and CXCR2 in LGG vs. GBM to identify molecular distinctions using datasets available on The Cancer Genome Atlas (TCGA). Methods: DNA sequencing and mRNA expression data for 514 brain lower grade glioma (LGG) and 592 glioblastoma multiforme (GBM) patients were acquired from The Cancer Genome Atlas (TCGA), and the genetic alterations and expression levels of the selected genes were analyzed. Results: We identified six distinct KDR mutations in the LGG patients and 18 distinct KDR mutations in the GBM patients, including missense and nonsense mutations, frame shift deletion and altered splice region. Furthermore, VEGFA and CXCL8 were significantly overexpressed within GBM patients. Conclusions: VEGFA and CXCL8 are important factors for angiogenesis, which are suggested to have significant roles during tumorigenesis. Our results provide further evidence that VEGFA and CXCL8 could induce angiogenesis and promote LGG to progress into GBM. These findings could be useful in developing novel targeted therapeutics approaches in the future.
dc.identifier.doi10.1590/0004-282X20190131
dc.identifier.endpage38
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue1
dc.identifier.pmid32074192
dc.identifier.scopus2-s2.0-85079674839
dc.identifier.scopusqualityQ3
dc.identifier.startpage34
dc.identifier.urihttps://doi.org/10.1590/0004-282X20190131
dc.identifier.urihttps://hdl.handle.net/11480/14566
dc.identifier.volume78
dc.identifier.wosWOS:000514570400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectbrain tumor
dc.subjectangiogenesis
dc.subjectgenetics
dc.titleA comprehensive analysis of the angiogenesis-related genes in glioblastoma multiforme vs. brain lower grade glioma
dc.typeArticle

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