Usage of natural chitosan membrane obtained from insect corneal lenses as a drug carrier and its potential for point of care tests

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dc.authoridZang, Lian-Sheng/0000-0002-9964-0512
dc.authoridIlk, Sedef/0000-0002-6754-792X
dc.authoridOnses, Mustafa Serdar/0000-0001-6898-7700
dc.authoridTorun, Ilker/0000-0001-9820-6565
dc.authoridAydin, Omer/0000-0002-9028-8786
dc.contributor.authorIkl, Sedef
dc.contributor.authorRamanauskaite, Aurelija
dc.contributor.authorBilican, Behlul Koc
dc.contributor.authorMulercikas, Povilas
dc.contributor.authorCam, Dilek
dc.contributor.authorOnses, M. Serdar
dc.contributor.authorTorun, Ilker
dc.date.accessioned2024-11-07T13:35:07Z
dc.date.available2024-11-07T13:35:07Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractChitosan is an indispensable biopolymer for use as a drug carrier thanks to its non-toxic, biodegradable, biocompatible, antimicrobial, and anti-oxidative nature. In previous studies, chitosan was first dissolved into weak acids and formed into gel, then used for carrying pharmaceutically active compounds such as nanoparticles, capsules, composites, and films. Using the produced chitosan gel after dissolving it in weak acids has advantages, such as ease of processing for loading the required amount of active substance and making the desired shape and size. However, dissolved chitosan loses some of its natural properties such as fibrous structure, crystallinity, and thermal stability. In this study, for the first time, three-dimensional chitosan lenses obtained from an insects (Tabanus bovinus) compound eyes, with the original shape intact, were tested as a drug carrier. A model drug, quercetin, was loaded into chitosan membrane, and its release profile was examined. Also, a point-of-care test was conducted for both chitin and chitosan membranes. Chitin and chitosan membranes obtained from insect corneal lenses were characterized by using FTIR, TGA, elemental analysis, and surface wettability analysis as well as stereo, binocular, and scanning electron microscopies. It was observed that chitosan membrane could be used as a drug carrier material. Both chitin and chitosan membranes will be improved for lateral flow assay, and these membranes can be tested for other bioengineering applications in further studies.
dc.identifier.doi10.1016/j.msec.2020.110897
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid32409054
dc.identifier.scopus2-s2.0-85082513710
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.msec.2020.110897
dc.identifier.urihttps://hdl.handle.net/11480/16348
dc.identifier.volume112
dc.identifier.wosWOS:000532843000027
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Science and Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectInsect eyes
dc.subjectChitin
dc.subjectChitosan
dc.subjectDrug carrier
dc.subjectQuercetin
dc.subjectPoint of care test
dc.titleUsage of natural chitosan membrane obtained from insect corneal lenses as a drug carrier and its potential for point of care tests
dc.typeArticle

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