Does Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities

Basit Öğe Kaydı
dc.contributor.authorBouhedda, Amina
dc.contributor.authorLaouer, Hocine
dc.contributor.authorSouilah, Nabila
dc.contributor.authorCakir, Cansel
dc.contributor.authorBouriah, Nacera
dc.contributor.authorAbu-Elsaoud, Abdelghafar M.
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-11-07T13:35:27Z
dc.date.available2024-11-07T13:35:27Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractGeraniaceae are typically used as diuretic, anti-diarrhoeal, stomachic, and anti-hemorrhagic drugs. This study examined the phytochemicals and bioactivities in methanolic extract (ME) and petroleum ether extract (PEE) of the Erodium trifolium aerial part. Inductively coupled plasma mass spectrometry was used to assess the mineral profiles, high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) and high-performance liquid chromatography with diode-array detection (HPLC-DAD) were used to assess the phenolic content of ME, and gas chromatography-mass spectrometry (GC-MS) was used to assess the fatty acid and volatile composition of the PEEs. In addition, the bioactivities of extracts were evaluated by using the 1,1-diphenyl-2-picrylhydrazyl, ABTS, and cupric reducing antioxidant capacity assays, including enzyme inhibition against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, alpha-glucosidase activities, and antibacterial properties. HPLC-MS identified eight compounds in ME: rutin, catechin, and caffeine were the major phenolic compounds detected. HPLC-DAD analysis showed that 11 compounds detected among epicatechin, catechin, chlorogenic acid, and gallic acid were predominant. GC-MS analysis revealed 30 fatty acids in PEE, with palmitic acid and oleic acid being predominant. The mineral content showed that Fe was the abundant microelement, and Ca and K were the abundant macroelements. The ME exhibited the highest activity compared to the PEE in all tests regarding antioxidant and antibacterial activities. Furthermore, all the extracts showed moderate inhibition against AChE, BChE, alpha-amylase, and alpha-glucosidase. In conclusion, E. trifolium may be employed to separate novel bioactive metabolites with potential pharmaceutical activities.
dc.description.sponsorshipDeanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) [IMSIU-RPP2023030]
dc.description.sponsorshipThis work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) (grant number IMSIU-RPP2023030).
dc.identifier.doi10.1515/chem-2024-0049
dc.identifier.issn2391-5420
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85197408630
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1515/chem-2024-0049
dc.identifier.urihttps://hdl.handle.net/11480/16514
dc.identifier.volume22
dc.identifier.wosWOS:001252180300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDe Gruyter Poland Sp Z O O
dc.relation.ispartofOpen Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectErodium trifolium
dc.subjectphenolic compounds
dc.subjectHPLC-DAD
dc.subjectfatty acid
dc.subjectminerals
dc.subjectbiological activity
dc.titleDoes Erodium trifolium (Cav.) Guitt exhibit medicinal properties? Response elements from phytochemical profiling, enzyme-inhibiting, and antioxidant and antimicrobial activities
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu