NEW SULFONYLHYDRAZONES CONTAINING METHANE SULFONIC ACID HYDRAZIDE HAVING HUMAN ANTI-CARBONIC ANHYDRASE AND ANTI- MICROBIAL ACTIVITY: SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, ELECTROCHEMICAL PROPERTIES, AND BIOLOGICAL ACTIVITIES

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dc.contributor.authorUzun, Demet
dc.contributor.authorErdogdu, Ebru
dc.contributor.authorGunduzalp, Ayla Balaban
dc.contributor.authorOzdemir, Ummuhan Ozmen
dc.contributor.authorOzturk, Ali
dc.contributor.authorOzbek, Neslihan
dc.contributor.authorKaya, Kerem
dc.date.accessioned2024-11-07T13:35:01Z
dc.date.available2024-11-07T13:35:01Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this work, new sulfonylhydrazones nomenclatured as 3,5-ditertbutylsalicylaldehyde methanesulfonylhydrazone (II), 3-tertbutylsalicylaldehyde methanesulfonylhydrazone (III), and 5-bromosalicylaldehyde methanesulfonylhydrazone (IV) were synthesized by the reaction of methanesulfonicacidhydrazide (I) with 3,5-ditertbutylsalicylaldehyde, 3-tertbutylsalicyl aldehyde, and 5-bromosalicylaldehyde. The structures of the aromatic sulfonylhydrazones were determined by using elemental analysis, UV-Vis, FT-IR, H-1-NMR, and C-13-NMR methods. The structure of IV was also supported with the X-ray diffraction method. Sulfonamides were generally investigated for their inhibitory effects on human carbonic anhydrase isoenzymes (hCAs). Synthesized alkylsulfonylhydrazones have a sulfonamide group, which is the most important pharmacophore for the carbonic anhydrase (CA) inhibition efficiency like the reference agent acetazolamide (AAZ). The enzyme inhibition trends of alkylsulfonylhydrazones on the hCA I isoenzyme were qualitatively investigated by cyclic voltammetry (CV) and differantial pulse voltammetry (DPV). Also, the inhibition activities of sulfonylhydrazones were determined by using UV-Vis spectrophotometry, and their inhibition parameters, such as K-m, IC50, and K-i, were calculated. Among the tested compounds, IV was found to be the most active compound on the hCA I isoenzyme with an IC50 value of 4.86x10(-6) M, whereas II and III were found to be the least potent compounds on hCA I with an IC50 value of 3.96x10(-4) M and 5.58x10(-5) M, respectively. All of the compounds showed excellent inhibition activity against gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Stenotrophomonas maltophilia) and gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidi), with minimum inhibitory concentration (MIC) values less than that of standard drugs (sulfamethoxazole and sulfisoxazole). In addition, all of the compounds exhibited excellent antifungal inhibition against C. albicans and A. fumigatus, with MIC values of 8-16 mu g/ml, which were 2-4 fold higher than the standard drug fluconazole (32 mu g/ml).
dc.description.sponsorshipGazi University, Ankara-Turkey
dc.description.sponsorshipThis work was supported by Gazi University, Ankara-Turkey.
dc.identifier.doi10.20450/mjcce.2021.2416
dc.identifier.endpage196
dc.identifier.issn1857-5552
dc.identifier.issn1857-5625
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85124000531
dc.identifier.scopusqualityQ4
dc.identifier.startpage181
dc.identifier.urihttps://doi.org/10.20450/mjcce.2021.2416
dc.identifier.urihttps://hdl.handle.net/11480/16289
dc.identifier.volume40
dc.identifier.wosWOS:000747339100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Chemists Technologists Madeconia
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectsulfonylhydrazones
dc.subjecthCA I isoenzyme
dc.subjectcyclic voltammetry (CV)
dc.subjectminimum inhibitory concentrations (MICs)
dc.titleNEW SULFONYLHYDRAZONES CONTAINING METHANE SULFONIC ACID HYDRAZIDE HAVING HUMAN ANTI-CARBONIC ANHYDRASE AND ANTI- MICROBIAL ACTIVITY: SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, ELECTROCHEMICAL PROPERTIES, AND BIOLOGICAL ACTIVITIES
dc.typeArticle

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