STAT3 expression is correlated with pathological stage in luminal subtypes of breast carcinoma

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dc.contributor.authorEroglu, M.
dc.contributor.authorKokenek-Unal, T. D.
dc.contributor.authorAkin-Bali, D. F.
dc.contributor.authorKirimlioglu, S. H.
dc.date.accessioned2024-11-07T13:33:00Z
dc.date.available2024-11-07T13:33:00Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAIM: STATs and HIFs in human solid tumors play an important role in mechanisms of tumor growth. The aim of this study was to determine the prognostic role of STATs and HIFs in breast cancers. METHODS: Twenty-four breast carcinoma cases who underwent mastectomy and axillary dissection were included into the study. The presence of STATs and HIFs in 24 breast cancer cases was evaluated immunohistochemically. We evaluated the differences in tumor grade, diameter, limits, intratumor desmoplasia, inflammatory infiltration, necrosis, axillary lymph node involvement, estrogen, progesterone and CerbB2 staining. RESULTS: In this study, the presence of STATs and HIFs expressions in breast tumors is shown. In our study, no statistically significant correlation was found between tumor grade, diameter, limits, intratumor desmoplasia, inflammatory infiltration, necrosis, axillary lymph node involvement, CerbB2 staining status and STATs and HIFs expressions. However, STAT5a and estrogen staining and HIF2 alpha and progesterone staining were found statistically significant. In addition, STAT3 expression was found to have significantly higher correlation with luminal breast cancer. CONCLUSIONS: The findings suggest that STATs and HIFs may play a role in the development of invasive ductal carcinomas; concerning their future use as treatment options due to their association with hormone receptors, new studies are required (Tab. 6, Fig. 7, Ref. 65).
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2008/30]
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Unit with the project number of 2008/30.
dc.identifier.doi10.4149/BLL_2020_008
dc.identifier.endpage61
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1
dc.identifier.pmid31950840
dc.identifier.scopus2-s2.0-85077940697
dc.identifier.scopusqualityQ3
dc.identifier.startpage51
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_008
dc.identifier.urihttps://hdl.handle.net/11480/15735
dc.identifier.volume121
dc.identifier.wosWOS:000507926100008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAepress Sro
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectBreast carcinoma
dc.subjectprognostic characteristics
dc.subjectHIFI a
dc.subjectHIF2a
dc.subjectSTAT1
dc.subjectSTAT2
dc.subjectSTAT3
dc.subjectSTAT5a
dc.subjectSTAT5b
dc.titleSTAT3 expression is correlated with pathological stage in luminal subtypes of breast carcinoma
dc.typeArticle

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