A significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome

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dc.authoridSari, Ismail/0000-0003-3732-2102
dc.contributor.authorKaydok, Ercan
dc.contributor.authorOzmen, Esma
dc.contributor.authorSari, Ismail
dc.contributor.authorSen Cakiroglu, Gozde
dc.contributor.authorTas, Ayca
dc.contributor.authorSilig, Yavuz
dc.contributor.authorHayta, Emrullah
dc.date.accessioned2024-11-07T13:34:10Z
dc.date.available2024-11-07T13:34:10Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractFibromyalgia syndrome (FMS) is a multifactorial disease characterized by chronic diffuse pain. Genetic factors are also involved in the etiology. However, there is not enough information on the genetic factors that play a role in the pathogenesis of FMS. This study aims to investigate the relationship between estrogen receptor 1 gene (ESRI) 594G>A (rs2228480) and 325C>G (rs2295190) polymorphisms and FMS. A total of 294 women, 146 of who were FMS patients and 148 of whom were healthy controls, were enrolled in the study. The instruments used to collect data from patients included patient follow-up forms, Visual Analog Scale (VAS), and Fibromyalgia Impact Questionnaire (FIQ). Genotyping of ESR1 594G>A and 325C>G polymorphisms in the extracted DNA samples was performed using an RT-PCR device and TaqMan hydrolysis probes. it was found that, for rs2295190 polymorphism, patients with CO and GO genotypes versus CC genotypes showed a decreased risk for FMS (OR: 0.442; 95% CI: 0.234-0.833). But there were no significant differences were found in the genotype distribution of rs2228480 polymorphism between the FMS patients and controls. The intragroup evaluation of FMS patients revealed no significant association between symptoms, pain score, FIQ score, and polymorphisms (p>0.05). We believe that there is a significant association between ESR1 rs2295190 polymorphism and FMS and that this polymorphism may be protective against FMS. However, there is a need for comprehensive studies on different populations to obtain clearer data as well as further studies to elucidate the possible mechanism of association. Copyright: (C) 2022 by the C.M.B. Association. All rights reserved.
dc.description.sponsorshipScientific Research Project Fund of Nigde Omer Halisdemir University [2019/4-BAGEP]
dc.description.sponsorshipThis study was supported by the Scientific Research Project Fund of Nigde Omer Halisdemir University (Project No: 2019/4-BAGEP).
dc.identifier.doi10.14715/cmb/2022.68.7.30
dc.identifier.endpage187
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue7
dc.identifier.pmid36495498
dc.identifier.scopus2-s2.0-85143917630
dc.identifier.scopusqualityQ4
dc.identifier.startpage182
dc.identifier.urihttps://doi.org/10.14715/cmb/2022.68.7.30
dc.identifier.urihttps://hdl.handle.net/11480/15844
dc.identifier.volume68
dc.identifier.wosWOS:000898196800030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectFibromyalgia
dc.subjectestrogen receptor 1
dc.subjectpolymorphism
dc.subjectsymptom
dc.subjectpain
dc.titleA significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome
dc.typeArticle

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