The relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome

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dc.authoridSEYDEL, GONUL SEYDA/0000-0001-9317-0719
dc.authoridGunturk, Inayet/0000-0002-8299-1359
dc.contributor.authorSeydel, Gonul Seyda
dc.contributor.authorGunturk, Inayet
dc.contributor.authorAkkaya, Hasan
dc.contributor.authorGunturk, Ertugrul Emre
dc.date.accessioned2024-11-07T13:31:42Z
dc.date.available2024-11-07T13:31:42Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackgroundInflammation plays a crucial role in the progression of acute coronary syndrome.AimsThe aim of this study was to investigate the relationship between the SYNTAX score and new inflammatory markers including albumin-globulin ratio (AGR), C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), and neutrophil percentage-to-albumin ratio (NPAR) in STEMI and NSTEMI patients.MethodsThe study involved 53 STEMI and 64 NSTEMI patients, and each patient group was evaluated separately. Multivariate linear regression analysis was utilised to identify independent risk factors associated with SYNTAX scores.ResultsOut of the 64 NSTEMI patients, 42 had low SYNTAX score (65.6%), and 22 had high SYNTAX score (34.4%). Patients with high SYNTAX scores had significantly higher levels of age, glucose, fibrinogen, monocyte, and FAR, and lower levels of albumin and total protein. We found that FAR and monocyte levels were independent predictors of the high SYNTAX score. The study also determined that the cut-off value for FAR as 9.99, with a sensitivity of 81% and a specificity of 73% for predicting high SYNTAX score in NSTEMI patients. Out of the 53 STEMI patients, 42 had low SYNTAX score (79.2%), and 11 had high SYNTAX score (20.8%). Patients with high SYNTAX scores exhibited significantly higher total cholesterol, LDL, and glucose levels, and lower albumin and total protein levels.ConclusionsThe FAR level is significantly linked with the high SYNTAX score and can be a useful marker for predicting the severity of disease in NSTEMI patients.
dc.identifier.doi10.1080/00015385.2024.2403933
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.pmid39287020
dc.identifier.scopus2-s2.0-85204037605
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1080/00015385.2024.2403933
dc.identifier.urihttps://hdl.handle.net/11480/14994
dc.identifier.wosWOS:001314366100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofActa Cardiologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAcute coronary syndrome
dc.subjectfibrinogen-to-albumin ratio
dc.subjectinflammatory markers
dc.subjectSYNTAX score
dc.titleThe relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome
dc.typeArticle

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