ANALYSIS OF INTERLEUKIN-17, INTERLEUKIN-23, NEOPTERIN AND NESFATIN-1 LEVELS IN THE SERA OF HASHIMOTO PATIENTS

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dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorEren, Mehmet Ali
dc.contributor.authorBayraktar, Mustafa
dc.contributor.authorOzturk, Ali
dc.contributor.authorErdogdu, Hamza
dc.date.accessioned2024-11-07T13:32:34Z
dc.date.available2024-11-07T13:32:34Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Hashimoto's thyroiditis (HT) is an autoimmu-ne disorder affecting the thyroid gland and may present as goiter or atrophic thyroiditis that may result in various metabolic and inflammatory disorders. The aim of this study is to determine the changes in serum levels of inter-leukin-17 (IL-17), IL-23, neopterin, and nesfatin-1 para-meters in HT patients and to evaluate the possible relati-onship among these parameters.Methods: 90 HT patients and 30 healthy individuals were included in this study. Demographic data of the patients included in the study were recorded and detailed physical examinations were performed. IL-17, IL-23, neopterin, and nesfatin-1 levels were measured in the serum samples of the participants by the ELISA method.Results: Serum IL-17, IL-23, neopterin, levels were signifi-cantly higher and nesfatin-1 levels were significantly lower in the HT group compared to the control group. Statistically significant differences were observed between all the groups except euthyroid HT versus HT treated with levothyroxine for nesfatin-1 at the 0.05 level.Conclusion: IL-17, IL-23, and neopterin were involved in the etiopathogenesis of HT. Weight gain in HT may due to low nesfatin-1 level rather than throid hormone deficiency. These variables could be used as potential biomarkers in the diagnosis, prognosis and fellow up of HT disease.
dc.description.sponsorshipHarran University, Turkey [21179]
dc.description.sponsorshipThis research was supported by the scientific research coordinatorship of Harran University, Turkey (Project no 21179).
dc.identifier.doi10.5937/jomb0-40683
dc.identifier.endpage468
dc.identifier.issn1452-8258
dc.identifier.issn1452-8266
dc.identifier.issue3
dc.identifier.pmid37790207
dc.identifier.scopus2-s2.0-85173164053
dc.identifier.scopusqualityQ3
dc.identifier.startpage460
dc.identifier.urihttps://doi.org/10.5937/jomb0-40683
dc.identifier.urihttps://hdl.handle.net/11480/15481
dc.identifier.volume42
dc.identifier.wosWOS:001044436200015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Medical Biochemists Serbia
dc.relation.ispartofJournal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectHashimoto's thyroiditis
dc.subjectInterleukin-17
dc.subjectInterleukin-23
dc.subjectNesfatin-1
dc.subjectNeopetrin
dc.titleANALYSIS OF INTERLEUKIN-17, INTERLEUKIN-23, NEOPTERIN AND NESFATIN-1 LEVELS IN THE SERA OF HASHIMOTO PATIENTS
dc.typeArticle

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