Inhibitory Effect of Valsartan on Pterygium Fibroblasts

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dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.contributor.authorKucuk, Erkut
dc.contributor.authorAydemir, Isil
dc.contributor.authorZor, Kursad Ramazan
dc.contributor.authorOzkan, Oktay
dc.date.accessioned2024-11-07T13:24:54Z
dc.date.available2024-11-07T13:24:54Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: Angiotensin receptor blockers (ARBs) were shown to have antifibrotic properties in ocular and systemic diseases. In this study, our aim was to investigate the effect of an angiotensin receptor blocker, valsartan, on pterygium fibroblasts and compare this effect with that of mitomycin C (MMC). Methods: Pterygium tissue samples were obtained from 3 patients during surgical excision. Primary cultured pterygium fibroblasts and L929 cell cultures were treated with different concentrations of MMC and valsartan. Results: The cell viability decreased with increasing concentrations of valsartan at 48 hours for both cell types. MMC inhibited the proliferation of both cell types at 48 hours. Both agents significantly decreased the cell migration of the 2 cell types, although it was more prominent in the MMC-treated group. Conclusions: Valsartan inhibited the proliferation and migration of pterygium fibroblasts. The known favorable safety profile of these drugs and the results of this study showing inhibitory effect on pterygium fibroblasts make valsartan a potential therapeutic agent for pterygium treatment.
dc.identifier.doi10.1097/ICO.0000000000002409
dc.identifier.endpage1144
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue9
dc.identifier.pmid32558732
dc.identifier.scopus2-s2.0-85089300711
dc.identifier.scopusqualityQ1
dc.identifier.startpage1139
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000002409
dc.identifier.urihttps://hdl.handle.net/11480/14373
dc.identifier.volume39
dc.identifier.wosWOS:000571175100013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectpterygium
dc.subjectvalsartan
dc.subjectcell culture
dc.subjectmitomycin C
dc.subjectfibrosis
dc.titleInhibitory Effect of Valsartan on Pterygium Fibroblasts
dc.typeArticle

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