IN VIVO HEPATOPROTECTIVE EFFECTS OF Hypericum crenulatum BOISS ON NIMESULIDE-INDUCED TOXICITY IN MICE

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dc.contributor.authorOzkan, Oktay
dc.contributor.authorOzbey, Caner
dc.contributor.authorArat, Gonca Donmez
dc.contributor.authorKart, Asim
dc.contributor.authorSari, Ismail
dc.contributor.authorAydemir, Isil
dc.date.accessioned2024-11-07T13:31:57Z
dc.date.available2024-11-07T13:31:57Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPlants of Hypericaceae family including many species have been used for the treatment of various dieases such as melancholia, abdominal pain, wound, tumor and oxidative stress in folk medicine. Hypericum crenulatum Boiss is a member of this family and is found throughout Bolkar mount from Meydan Yayla to San Tepe. It is an endemic herbaceous perennial plant. It is aimed to investigate in this study whether this plant specie have a hepatoprotective properties against nimesulide-induced liver injury in mice. According to the results of the study, methanolic extract of Hypericum crenulatum Boiss showed significant differences on serum ALP and liver histopathology. However, serum AST and ALT values, TAS, TOS and OSI were not altered. Hypericum crenulatum Boiss significant improvement Boiss extract at low dose provided a in nimesulide-induced acute liver toxicity. The data indicate that methanolic extract of Hypericum crenulatum Boiss is considered to be effective against liver toxicity.
dc.description.sponsorshipResearch Fund of the Nigde Omer Halisdemir University [SSB 2017/05-BAGEP]
dc.description.sponsorshipThis work was supported by Research Fund of the Nigde Omer Halisdemir University. Project Number: SSB 2017/05-BAGEP
dc.identifier.endpage2971
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue3
dc.identifier.startpage2962
dc.identifier.urihttps://hdl.handle.net/11480/15148
dc.identifier.volume31
dc.identifier.wosWOS:000766411400069
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectHypericum crenulatum Boiss
dc.subjectNimesulide
dc.subjectAntioxidant activity
dc.subjectHepatotoxicity
dc.subjectIn vivo
dc.titleIN VIVO HEPATOPROTECTIVE EFFECTS OF Hypericum crenulatum BOISS ON NIMESULIDE-INDUCED TOXICITY IN MICE
dc.typeArticle

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