The investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes

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dc.authoridceyhan, ayhan/0000-0003-2862-7369
dc.authoridHasan, Mubeen ul/0000-0001-7435-4619
dc.contributor.authorHasan, Mubeen Ul
dc.contributor.authorCeyhan, Ayhan
dc.date.accessioned2024-11-07T13:24:13Z
dc.date.available2024-11-07T13:24:13Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground Livestock farmers face financial losses every year because milk yield and components are severely affected by udder diseases. These udder infections attract the immune response from the host and lead to the influx of neutrophils into milk to fight infection and thus the number of somatic cell count (SCC) is increased. The SCC value of milk could be used as an important indicator in detecting clinical mastitis in dairy animals. Also, the milk yield and milk quality (e.g. fat) are negatively affected by the increased SCC. The SCC is used to estimate the somatic cell score (SCS)of the milk, which is used as an indirect measure to detect subclinical mastitis. Therefore, the purpose of this study was to investigate the presence of a significant SNP rs868996547, on the suppressor of cytokine signaling 2 gene (SOCS2) which is related to milk yield and milk quality in Awassi sheep. Methods In this study, milk production data was obtained from 210 healthy Awassi ewes with different parties and ages. The general linear model (GLM) process analysis of variance (ANOVA) was used to determine fixed effects on milk traits. The DNA extraction was done using a blood DNA extraction kit from Qiagen. To validate the presence of SNP a customized SNP detection developed by Thermofisher Scientific was used. The presence of the SNP in the SOCS2 gene was detected with genotypes (C/T, T/T, and C/C) and T being the mutated allele and it had a significant (p < 0.015) effect on the milk yield (p < 0,015;0.091), fat (p < 0,001;0,003), fat/protein ratio (p < 0.001;0,037) and log10SCC value (p < 0,006;0,015) of Awassi ewes. However, the protein, total solid, and lactose percentages in the wild type and the mutated ewes found having no significant difference (P > 0.05). Conclusion Our result showed the increase in SCC or SCS of the milk significantly affected the milk yield and composition. Parity and age had significant effects on ewes' milk yield (p < 0.001). In conclusion, we investigated the presence of SOCS2 gene of Awassi ewes in the study flock and its effect on milk yield, fat, and somatic cell count, and the change in milk composition and milk yield because of SCC.
dc.description.sponsorshipBAP funding Commission of Nigde OEmer Halidemir University
dc.description.sponsorshipThe research was funded by the BAP funding Commission of Nigde OEmer Halidemir University.
dc.identifier.doi10.1007/s11250-024-04147-z
dc.identifier.issn0049-4747
dc.identifier.issn1573-7438
dc.identifier.issue8
dc.identifier.pmid39312078
dc.identifier.scopus2-s2.0-85204757351
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11250-024-04147-z
dc.identifier.urihttps://hdl.handle.net/11480/13965
dc.identifier.volume56
dc.identifier.wosWOS:001320776400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTropical Animal Health and Production
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectMilk content
dc.subjectSomatic cell count
dc.subjectSingle Nucleotide Polymorphism
dc.subjectGenes
dc.subjectAwassi Sheep
dc.titleThe investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes
dc.typeArticle

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