Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

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dc.authoridZhang, Baozhong/0000-0002-7308-1572
dc.authoridIlk, Sedef/0000-0002-6754-792X
dc.authoridLi, Xiaoya/0000-0003-1797-7398
dc.contributor.authorArza, Carlos R.
dc.contributor.authorLi, Xiaoya
dc.contributor.authorIlk, Sedef
dc.contributor.authorLiu, Yang
dc.contributor.authorDemircan, Deniz
dc.contributor.authorZhang, Baozhong
dc.date.accessioned2024-11-07T13:34:52Z
dc.date.available2024-11-07T13:34:52Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThis work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.
dc.description.sponsorshipAForsk Foundation [16-479]; Mistra Foundation (the STEPS project) [2016/1489]; Swedish Research Council for Sustainable Development (Formas) [2021-01107]; Crafoord Foundation [20160774, 20180939]; Royal Physiographic Society in Lund; Guangzhou Elite Project (GEP); Swedish Research Council [2021-01107] Funding Source: Swedish Research Council; Formas [2021-01107] Funding Source: Formas
dc.description.sponsorshipThis research was financed by the angstrom Forsk Foundation (No. 16-479), Mistra Foundation (the STEPS project, No. 2016/1489), Swedish Research Council for Sustainable Development (Formas, No. 2021-01107), the Crafoord Foundation (No. 20160774 and 20180939), the Royal Physiographic Society in Lund, and Guangzhou Elite Project (GEP). We thank Sofia Essen and Katja Bernfur for mass spectrometry measurements, Niklas Warlin and Bona AB for SEC measurements, and Jingyi Rao, Sujeesh Sebastian, and Deepak Raina for valuable discussions.
dc.identifier.doi10.1039/d2tb01233b
dc.identifier.endpage8074
dc.identifier.issn2050-750X
dc.identifier.issn2050-7518
dc.identifier.issue39
dc.identifier.pmid36111601
dc.identifier.scopus2-s2.0-85139804114
dc.identifier.scopusqualityQ1
dc.identifier.startpage8064
dc.identifier.urihttps://doi.org/10.1039/d2tb01233b
dc.identifier.urihttps://hdl.handle.net/11480/16217
dc.identifier.volume10
dc.identifier.wosWOS:000854204700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofJournal of Materials Chemistry B
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectOne-Step Synthesis
dc.subjectOf-The-Art
dc.subjectAntibacterial Activity
dc.subjectThermal-Properties
dc.subjectDerivatives
dc.subjectIndole
dc.subjectPolyesters
dc.subjectDendrimers
dc.subjectChitosan
dc.subjectMonomer
dc.titleBiocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units
dc.typeArticle

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