Melatonin and Respiratory Diseases: A Review

Basit Öğe Kaydı
dc.authorid0000-0003-2101-616X
dc.authorid0000-0001-8656-6838
dc.contributor.authorHabtemariam, Solomon
dc.contributor.authorDaglia, Maria
dc.contributor.authorSureda, Antoni
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorGulhan, Mehmet Fuat
dc.contributor.authorNabavi, Seyed Mohammad
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2017
dc.departmentNiğde ÖHÜ
dc.description.abstractMelatonin is an indoleamine with potent multifunctional biological and pharmacological effects, both receptor dependent and receptor-independent effects, including antioxidant, anticancer, antitumor, anti-inflammatory, anti-aging, anti-diabetic, antiviral, neuroprotective activities. Melatonin mitigates tissue injury via modification of abnormalities in redox status and other biochemical markers. At the molecular level, the biological and pharmacological activities of melatonin are attributed to the inhibition of nuclear factor-.appa beta (NF-kappa beta), c-Fos over expression and down-regulation of matrix metalloproteinases-3 (MMP-3), which are regulators of pro-inflammatory and pro-fibrotic cytokines. There are numerous scientific reports on the therapeutic potential of melatonin in treatment of asthma, respiratory diseases for infections, chronic obstructive pulmonary disease, lung cancer, pleural cavity diseases, as well as vascular pulmonary disease. In the present communication, we systematically review the therapeutic potential of melatonin in the treatment of respiratory diseases along with its molecular mechanism of actions.
dc.identifier.doi10.2174/1568026616666160824120338
dc.identifier.endpage488
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.issue4
dc.identifier.pmid27558675
dc.identifier.scopus2-s2.0-85011954049
dc.identifier.scopusqualityQ2
dc.identifier.startpage467
dc.identifier.urihttps://dx.doi.org/10.2174/1568026616666160824120338
dc.identifier.urihttps://hdl.handle.net/11480/3532
dc.identifier.volume17
dc.identifier.wosWOS:000392081500010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT TOPICS IN MEDICINAL CHEMISTRY
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-inflammatory
dc.subjectAntioxidant
dc.subjectLung disease
dc.subjectMelatonin
dc.subjectPulmonary disease
dc.subjectRespiratory disorders
dc.titleMelatonin and Respiratory Diseases: A Review
dc.typeReview Article

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