Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients

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dc.authoridSari, Ismail/0000-0003-3732-2102
dc.contributor.authorZor, Ramazan Kursad
dc.contributor.authorErsan, Serpil
dc.contributor.authorKucuk, Erkut
dc.contributor.authorYildirim, Gamze
dc.contributor.authorSari, Ismail
dc.date.accessioned2024-11-07T13:31:33Z
dc.date.available2024-11-07T13:31:33Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPurpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants (n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group (p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group (p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.
dc.identifier.doi10.1177/2515841420951682
dc.identifier.issn2515-8414
dc.identifier.pmid33062929
dc.identifier.scopus2-s2.0-85104536262
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1177/2515841420951682
dc.identifier.urihttps://hdl.handle.net/11480/14918
dc.identifier.volume12
dc.identifier.wosWOS:000576394200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofTherapeutic Advances in Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectage-related macular degeneration
dc.subjectchoroidal neovascularization
dc.subjectinflammation
dc.subjectmalondialdehyde
dc.subjectmonocyte chemoattractant protein-1
dc.subjectoxidative stress
dc.titleSerum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients
dc.typeArticle

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