Modulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthracene

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dc.authorid0000-0001-6080-229X
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorAtes, Burhan
dc.contributor.authorGok, Yetkin
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2013
dc.departmentNiğde ÖHÜ
dc.description.abstractObjective: The aim of this study was to evaluate the chemopreventive potential of organoselenium compounds (Se I and Se II) in the well-established rat model treated with 7,12-dimethylbenz[a]anthracene (DMBA), by monitoring the extent of tyrosine hydroxylase (TH) activity, adrenomedullin (ADM) level and total RNA level in adrenal medulla. Organic pollutants are the most important environmental factor for the biologic systems. DMBA exposure appears to be associated with a number of physiological disease processes. Methods: The effects of Se I and Se II compounds were investigated on TH activity, ADM and total RNA levels in adrenal medulla of rats exposed to DMBA. Results: TH activity, ADM and total RNA levels were found to be increased significantly due to the effect of DMBA (p < 0.05). This increase was restricted in the Se I-and Se II-treated groups (p < 0.05). Conclusion: The present data showed that the organoselenium compounds may have important effects in the maintainance of homeostasis against stress induced by DMBA.
dc.description.sponsorshipInonu University [BAP 2005/60]
dc.description.sponsorshipThis work was supported by Inonu University Research Fund (BAP 2005/60).
dc.identifier.doi10.1177/0748233711432575
dc.identifier.endpage292
dc.identifier.issn0748-2337
dc.identifier.issue3
dc.identifier.pmid22287620
dc.identifier.scopus2-s2.0-84875751032
dc.identifier.scopusqualityQ3
dc.identifier.startpage286
dc.identifier.urihttps://dx.doi.org/10.1177/0748233711432575
dc.identifier.urihttps://hdl.handle.net/11480/4418
dc.identifier.volume29
dc.identifier.wosWOS:000317523000007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofTOXICOLOGY AND INDUSTRIAL HEALTH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenal medulla
dc.subjectadrenomedullin
dc.subjectDMBA
dc.subjectrat
dc.subjectsynthetic organoselenium compounds
dc.subjecttyrosine hydroxylase
dc.titleModulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthracene
dc.typeArticle

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