Aromatase Enzyme Activity and Liver Receptor Homolog-1 Levels in Gestational Diabetes Mellitus

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dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorTaş, Hasip
dc.contributor.authorBayraktar, Mehmet
dc.contributor.authorKoyuncu, İsmail
dc.contributor.authorSarı, İsmail
dc.contributor.authorUyanıkoğlu, Hacer
dc.date.accessioned2024-11-07T10:40:01Z
dc.date.available2024-11-07T10:40:01Z
dc.date.issued2023
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Gestational diabetes mellitus (GDM) is one of the prediabetes conditions in which high blood sugar levels and body weight increase during pregnancy. The underlying molecular and biochemical mechanisms of GDM have been poorly defined. Introduction: Aromatase enzyme activity is responsible for the conversion of androgens to estrogens and has a share in the regulation of body fat distribution and liver receptor homolog-1 (LRH-1), which plays a critical role in cholesterol transport, acid homeostasis, and steroidogenesis in GDM patients. This study aims to determine the levels of aromatase enzyme and LRH-1 in GDM patients and to investigate the relationship between the levels of aromatase enzyme and LRH-1 and the levels of insulin, HbA 1c and total cholesterol. Methods: This prospective cross-sectional study was conducted over eleven months (September 2020 to July 2021). The study population was selected at Harran University Teaching and Research Hospital. The study included 32 GDM patients and 32 healthy pregnants. The automated assay measured serum fasting blood glucose, HbA1c, and insulin levels (AVIDA 1800 Chemistry System; Siemens). Aromatase enzyme activity and LRH-1 levels were determined by using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results: Aromatase activity decreased in GDM patients while LRH1 increased. Significant differences in means levels of fasting blood glucose (p = 0.11), insulin (p = 0.001) and HbA1c (p = 0.001) between the patients and control groups. There was a significant negative correlation between the levels of aromatase and insulin (r =-370, p = 0.037). In addition, a positive significant correlation coefficient (r = 0.645, p = 0.001) was found between HbA1c and total cholesterol among the patients' group. Conclusion: Our findings indicate that there is a negative relationship between aromatase activity and insulin levels. Aromatase and LRH 1 may play a role in the pathogenesis of GDM, and the use of LRH-1 agonists in treating the disease may be considered an alternative treatment in the future. However, additional studies are required to reveal the possible functions of these two proteins in GDM with their mechanisms. © 2023 Bentham Science Publishers.
dc.identifier.doi10.2174/1573408019666221103145729
dc.identifier.endpage54
dc.identifier.issn1573-4080
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85149667627
dc.identifier.scopusqualityQ4
dc.identifier.startpage49
dc.identifier.urihttps://doi.org/10.2174/1573408019666221103145729
dc.identifier.urihttps://hdl.handle.net/11480/11361
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Enzyme Inhibition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAromatase
dc.subjectdiabetes mellitus
dc.subjectgestation
dc.subjectHbA1c
dc.subjectinsulin
dc.subjectliver receptor homolog-1
dc.titleAromatase Enzyme Activity and Liver Receptor Homolog-1 Levels in Gestational Diabetes Mellitus
dc.typeArticle

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