Neurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury

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dc.authoridAziz, Nimra/0009-0006-3565-6853
dc.authoridALSHAWI, ALI/0000-0002-0690-4612
dc.authoridRasool, Bilal/0000-0002-4465-1169
dc.contributor.authorRasul, Azhar
dc.contributor.authorAl-Shawi, Ali A. A.
dc.contributor.authorMalik, Shoaib Ahmad
dc.contributor.authorAnwar, Haseeb
dc.contributor.authorRasool, Bilal
dc.contributor.authorRazzaq, Aroona
dc.contributor.authorAziz, Nimra
dc.date.accessioned2024-11-07T13:35:13Z
dc.date.available2024-11-07T13:35:13Z
dc.date.issued2019
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPeripheral nerve injury is a complex condition which results in restricted physical activity. Despite the tremendous efforts to figure out effective remedies, the complete functional retrieval is still a goal to be achieved. So, the need of hour is the exploration of potential natural compounds to recover this functional loss. Here, we have investigated the role of a local plant Neurada procumbens in ameliorating the functional recovery after an induced nerve compression injury in a mouse model. A dose of N. procumbens (50mg/kg of body weight) was administered orally from the day of injury to onwards. The motor functional recovery was assessed by evaluating muscle grip strength and sciatic functional index; while the sensory functions were gauged by the hotplate test. The serological parameters were carried out to analyze the effect of N. procumbens on oxidative stress level. The recovery of sensory and motor functions was significantly improved and perceived earlier in the treatment group. Moreover, the elevated antioxidant level was statistically significant in the treatment group. These results indicate that the supplementation of N. procumbens accelerates functional recovery after sciatic nerve crush injury.
dc.description.sponsorshipNagai Foundation Tokyo, Japan (NFT-R-2018); TWASCOMSTECH Research Grant [17-180 RG/PHA/AS_C]; NRPU [7612/Punjab/NRPU/R&D/HEC/2017,8381/Punjab/NRP U/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]
dc.description.sponsorshipThis study was supported by the research grant The Nagai Foundation Tokyo, Japan (NFT-R-2018), TWASCOMSTECH Research Grant (No.17-180 RG/PHA/AS_C) and NRPU Research Grants (7612/Punjab/NRPU/R&D/HEC/2017,8381/Punjab/NRP U/R&D/HEC/2017 and 8382/Punjab/NRPU/R&D/HEC/2017). We would also like to thank Higher Education Commission (HEC), Pakistan for providing access to related papers from various journals.
dc.identifier.endpage1766
dc.identifier.issn1011-601X
dc.identifier.issue4
dc.identifier.pmid31680070
dc.identifier.scopus2-s2.0-85074397401
dc.identifier.scopusqualityQ3
dc.identifier.startpage1761
dc.identifier.urihttps://hdl.handle.net/11480/16386
dc.identifier.volume32
dc.identifier.wosWOS:000485337600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUniv Karachi
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectPeripheral nerve injury
dc.subjectsensory functions recovery
dc.subjectmotor functions recovery
dc.subjectNeurada procumbens. oxidative stress
dc.titleNeurada procumbens promotes functions regain in a mouse model of mechanically induced sciatic nerve injury
dc.typeArticle

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