Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction

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dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.contributor.authorOzdemir, Betul
dc.contributor.authorSelamoglu, Zeliha
dc.contributor.authorBraidy, Nady
dc.coverage.doi10.1007/978-1-0716-0471-7
dc.date.accessioned2024-11-07T13:34:30Z
dc.date.available2024-11-07T13:34:30Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractApolipoproteins have important structural and functional roles in several lipoprotein particles. Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major regulatory roles in both pre- and pro-atherosclerotic mechanisms. They are also involved in protective mechanisms against atherosclerotic plaques. Therefore, accurate quantification of apolipoproteins may serve as a crucial biomarker for cardiovascular diseases. However, most apolipoproteins cannot be detected using standard clinical immunoassays, and multiplexing is not available for some species of apolipoproteins. Herein, we describe a highly robust and quantitative method using liquid chromatography coupled to tandem mass spectrometry to quantify apolipoproteins in plasma. This methodology may add clinical value for profiling cardiovascular risk in vulnerable individuals and enable monitoring of apolipoprotein levels in plasma following intervention strategies.
dc.description.sponsorshipAustralian Research Council Discovery Early Career Research Award at the University of New South Wales, Sydney, Australia
dc.description.sponsorshipN.B. is the recipient of the Australian Research Council Discovery Early Career Research Award at the University of New SouthWales, Sydney, Australia.
dc.identifier.doi10.1007/978-1-0716-0471-7_27
dc.identifier.endpage379
dc.identifier.isbn978-1-0716-0471-7
dc.identifier.isbn978-1-0716-0470-0
dc.identifier.issn1064-3745
dc.identifier.issn1940-6029
dc.identifier.pmid32219764
dc.identifier.scopus2-s2.0-85082561866
dc.identifier.scopusqualityQ3
dc.identifier.startpage373
dc.identifier.urihttps://doi.org/10.1007/978-1-0716-0471-7_27
dc.identifier.urihttps://hdl.handle.net/11480/16017
dc.identifier.volume2138
dc.identifier.wosWOS:000681362800028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofClinical and Preclinical Models For Maximizing Healthspan: Methods and Protocols
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectApolipoproteins
dc.subjectCardiovascular disease
dc.subjectMetabolism
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectAging
dc.titleAbsolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction
dc.typeBook Chapter

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