Endobronchial Primary Pulmonary Angiomatoid Fibrous Histiocytoma in a Patient with Testicular Germ Cell Tumor: An Evidence Against Somatic Transformation

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dc.authoridTurk, Ilteris/0000-0001-6385-4722
dc.authoridKosemehmetoglu, Kemal/0000-0002-7747-0460
dc.authoridCETIN, MEHMET/0000-0001-5471-2239
dc.contributor.authorCetin, Mehmet
dc.contributor.authorKatipoglu, Kubra
dc.contributor.authorTurk, Ilteris
dc.contributor.authorOzkara, Seref
dc.contributor.authorKosemehmetoglu, Kemal
dc.contributor.authorBicakcioglu, Pinar
dc.date.accessioned2024-11-07T13:34:15Z
dc.date.available2024-11-07T13:34:15Z
dc.date.issued2022
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractPrimary Pulmonary Angiomatoid Fibrous Histiocytoma is a recently described soft tissue tumor with challenging differential diagnosis both clinically and pathologically due to its rarity in this location. It may also occur as a secondary malignancy and its occurrence either as a somatic malignancy arising in the germ cell tumor or as a secondary malignancy after chemotherapy is questionable. In this report, we present a 29-year-old male patient with a mass in the lower lobe of the left lung, who underwent orchiectomy and received adjuvant chemotherapy due to a mixed germ cell tumor 8 years ago. Morphology, immunophenotype, and molecular findings were consistent with the diagnosis of primary pulmonary angiomatoid fibrous histiocytoma. Fluorescent in situ hybridization was unable to demonstrate the presence of 12p amplification or isochromosome 12p, which is known as the key event in the development of testicular germ cell neoplasia even present in somatic malignancies arising in germ cell tumors. Our results support that angiomatoid fibrous histiocytoma arising as a secondary malignancy does not represent the somatic transformation of germ cell tumors.
dc.identifier.doi10.1177/10668969221076548
dc.identifier.endpage667
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.issue6
dc.identifier.pmid35118896
dc.identifier.scopus2-s2.0-85124302110
dc.identifier.scopusqualityQ2
dc.identifier.startpage662
dc.identifier.urihttps://doi.org/10.1177/10668969221076548
dc.identifier.urihttps://hdl.handle.net/11480/15860
dc.identifier.volume30
dc.identifier.wosWOS:000752973100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal of Surgical Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectangiomatoid fibrous histiocytoma
dc.subjectendobronchial
dc.subjectpulmonary
dc.subjectsecondary malignancy
dc.subjecttesticular cancer
dc.titleEndobronchial Primary Pulmonary Angiomatoid Fibrous Histiocytoma in a Patient with Testicular Germ Cell Tumor: An Evidence Against Somatic Transformation
dc.typeArticle

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