Polyunsaturated fatty acids as a nutraceutical for age-related neurodegenerative diseases: Current knowledge and future directions

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dc.contributor.authorŞimşek, Hilal
dc.contributor.authorUçar, Aslı
dc.date.accessioned2024-11-07T10:40:18Z
dc.date.available2024-11-07T10:40:18Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAge-related neurodegeneration is an important public health challenge with the increasing burden of geriatric disease in the aging world population. Interest in nutraceuticals in the prevention and management of age-related neurodegeneration is therefore becoming more important than ever, especially in the management of neurodegenerative diseases and mild cognitive impairments, which are major contributors to the burden of geriatric disease. Polyunsaturated fatty acids are considered one of the most important nutraceuticals with their biochemical mechanisms, especially antioxidant and anti-inflammatory. Potential mechanisms by which PUFAs alleviate or prevent neurodegeneration include suppression of neuroinflammation and neurotoxicity, neuro-recovery, and support of the blood-brain barrier integrity. This review will consider the mechanisms and current information on the effect of supplementation or dietary intake of polyunsaturated fatty acids as nutraceuticals on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. © 2024 The Authors
dc.identifier.doi10.1016/j.nutos.2024.05.012
dc.identifier.endpage73
dc.identifier.issn2667-2685
dc.identifier.scopus2-s2.0-85195665406
dc.identifier.scopusqualityQ3
dc.identifier.startpage65
dc.identifier.urihttps://doi.org/10.1016/j.nutos.2024.05.012
dc.identifier.urihttps://hdl.handle.net/11480/11561
dc.identifier.volume56
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Nutrition Open Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectAlzheimer's disease
dc.subjectNeurodegeneration
dc.subjectNutraceuticals
dc.subjectParkinson's disease
dc.titlePolyunsaturated fatty acids as a nutraceutical for age-related neurodegenerative diseases: Current knowledge and future directions
dc.typeArticle

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