Cellulose-Organic Montmorillonite Nanocomposites as Biomacromolecular Quorum-Sensing Inhibitor

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dc.authoridIlk, Sedef/0000-0002-6754-792X
dc.authoridZhang, Baozhong/0000-0002-7308-1572
dc.authoridDemircan, Deniz/0000-0002-4511-1893
dc.contributor.authorDemircan, Deniz
dc.contributor.authorIlk, Sedef
dc.contributor.authorZhang, Baozhong
dc.date.accessioned2024-11-07T13:34:20Z
dc.date.available2024-11-07T13:34:20Z
dc.date.issued2017
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe aim of this study was to develop simple cellulose nanocomposites that can interfere with the quorum sensing (QS)-regulated physiological process of bacteria, which will provide a sustainable and inexpensive solution to the serious challenges caused by bacterial infections in various products like food packaging or biomedical materials. Three cellulose nanocomposites with 1-5 w% octadecylaminemodified montmorillonite (ODA-MMT) were prepared by regeneration of cellulose from ionic liquid solutions in the presence of ODA-MMT suspension. Structural characterization of the nanocomposites showed that the ODA-MMT can be exfoliated or intercalated, depending on the load level of the nanofiller. Thermal gravimetric analysis showed that the incorporation of ODA-MMT nanofiller can improve the thermal stability of the nanocomposites compared with regenerated cellulose. Evaluation of the anti-QS effect against a pigment-producing bacteria C. violaceum CV026 by disc diffusion assay and flask incubation assay revealed that the QS-regulated violacein pigment production was significantly inhibited by the cellulose nanocomposites without interfering the bacterial vitality. Interestingly, the nanocomposite with the lowest load of ODA-MMT exhibited the most significant anti-QS effect, which may be correlated to the exfoliation of nanofillers. To our knowledge, this is the first report on the anti-QS effect of cellulose nanocomposites without the addition of any small molecular agents. Such inexpensive and nontoxic biomaterials will thus have great potential in the development of new cellulosic materials that can effectively prevent the formation of harmful biofilms.
dc.description.sponsorshipRoyal Physiographic Society in Lund; Crafoord Foundation [20160774]; BAP, Hacettepe University [FBI-2015-7946]
dc.description.sponsorshipThis study was supported by The Royal Physiographic Society in Lund, the Crafoord Foundation (Project No. 20160774), and BAP, Hacettepe University, Project No. FBI-2015-7946. We thank Laura Folkers for XRD measurements.
dc.identifier.doi10.1021/acs.biomac.7b01116
dc.identifier.endpage3446
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.issue10
dc.identifier.pmid28841299
dc.identifier.scopus2-s2.0-85031304714
dc.identifier.scopusqualityQ1
dc.identifier.startpage3439
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.7b01116
dc.identifier.urihttps://hdl.handle.net/11480/15934
dc.identifier.volume18
dc.identifier.wosWOS:000412864900042
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofBiomacromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectAntimicrobial Activity
dc.subjectEssential Oils
dc.subjectIonic Liquids
dc.subjectExtract
dc.subjectMicroorganisms
dc.subjectAntibacterial
dc.subjectDissolution
dc.subjectAntioxidant
dc.subjectGeneration
dc.subjectComponents
dc.titleCellulose-Organic Montmorillonite Nanocomposites as Biomacromolecular Quorum-Sensing Inhibitor
dc.typeArticle

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