Alterations in the immunoreactivity of laminin, type IV collagen and ?3?1 integrin in diabetic rat ovarian follicles

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dc.authoridYildirim, Aysegul Burcin/0000-0001-7240-9997
dc.contributor.authorYildirim, A. B.
dc.contributor.authorKarabulut, D.
dc.contributor.authorOzturk, E.
dc.contributor.authorKaymak, E.
dc.contributor.authorYalcin, B.
dc.contributor.authorKuloglu, N.
dc.contributor.authorAkkus, E.
dc.date.accessioned2024-11-07T13:34:48Z
dc.date.available2024-11-07T13:34:48Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractAIM: In order to determine the possible effects of diabetes, we aimed to investigate the expression of extracellular matrix proteins in the theca and granulosa layers in different follicular stages. METHODS: Thirty-two adult Wistar albino male rats were divided into 4 groups as control and sampled groups. Four, eight and twelve weeks after inducing diabetes with an intraperitoneal injection of streptozotocin (40 mg/kg), the expressions of laminin, type IV collagen and alpha 3 beta 1 integrin in ovarian tissues were evaluated by immunohistochemical method. RESULTS: In our study, in the first month of diabetes, a significant increase was observed in laminin, type IV collagen and alpha 3 beta 1 integrin expressions in all follicle types compared to the control group in both the theca and granulosa layers. Laminin and type IV collagen immunoreactivity tended to increase in D2 and D3 groups also. Integrin expression did not change in the newly formed follicles in the D2 and D3 groups, however, it tended to change and increase in the developing follicles. CONCLUSIONS: The changes in the expression of laminin, type IV collagen and alpha 3 beta 1 integrin, which are the extracellular matrix proteins in the follicle, along with diabetes, show that diabetes plays a role in the regulation of follicular development (Tab. 4, Fig. 36, Ref. 29).
dc.description.sponsorshipErciyes University Scientific Research Projects
dc.description.sponsorshipThis study was supported by Erciyes University Scientific Research Projects.
dc.identifier.doi10.4149/BLL_2020_054
dc.identifier.endpage347
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5
dc.identifier.pmid32356431
dc.identifier.scopus2-s2.0-85085769575
dc.identifier.scopusqualityQ3
dc.identifier.startpage340
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_054
dc.identifier.urihttps://hdl.handle.net/11480/16157
dc.identifier.volume121
dc.identifier.wosWOS:000530579900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectalpha 3 beta 1 integrin
dc.subjectlaminin
dc.subjecttype IV collagen
dc.subjectdiabetes
dc.subjectIHC
dc.subjectovarian follicles
dc.titleAlterations in the immunoreactivity of laminin, type IV collagen and ?3?1 integrin in diabetic rat ovarian follicles
dc.typeArticle

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