Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats

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dc.authoridGunaydin, Bilal/0000-0001-8135-8175
dc.authoridyasar, adem/0000-0003-4029-1896
dc.contributor.authorFirat, Fatih
dc.contributor.authorErdemir, Fikret
dc.contributor.authorGunaydin, Bilal
dc.contributor.authorParlaktas, Bekir Suha
dc.contributor.authorMarkoc, Fatma
dc.contributor.authorYasar, Adem
dc.date.accessioned2024-11-07T13:34:16Z
dc.date.available2024-11-07T13:34:16Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIn this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was defined as orchiectomy and followed up for 1 month. Measurements of intracavernosal pressure with different electrical stimuli and pathological findings of smooth muscle collagen in cavernosal tissues were examined. While the cavernosal pressure response in all the different electrical stimuli given in the control group and in all other groups was significantly lower than that in the other groups, it was statistically significant at 7.5 and 10 V (p = .005, p < 0001). According to the pathologic evaluation, the density of tissue collagen increased significantly in the other groups according to the control group. In groups 3 and 4, the density of 4+ collagen was found to be increased according to Groups 1 and 2. In the LH-RH alone group, it appears that there are no 4+ colloid density and less damage. According to these findings, the negative effect of LH-RH treatment on cavernosal tissues appears to be less.
dc.identifier.doi10.1111/and.13567
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue5
dc.identifier.pmid32189380
dc.identifier.scopus2-s2.0-85081969078
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/and.13567
dc.identifier.urihttps://hdl.handle.net/11480/15878
dc.identifier.volume52
dc.identifier.wosWOS:000520242900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectcastration
dc.subjectcavernosal tissue
dc.subjecterection
dc.subjectintracavernosal pressure
dc.titleEvaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats
dc.typeArticle

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