Cardiac autonomic involvement in Huntington's disease

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dc.authoridiscan, dilek/0000-0002-0773-7780
dc.contributor.authorIscan, Dilek
dc.contributor.authorCetinkaya, Yakup
dc.date.accessioned2024-11-07T13:24:14Z
dc.date.available2024-11-07T13:24:14Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractIntroductionHuntington's disease (HD) is known as a neurodegenerative disease with movement disorder and cognitive impairment; autonomic involvement is also becoming common in some recent studies. The aim of this study is to demonstrate the presence of cardiac autonomic involvement in HD patients.MethodTime and frequency domain parameters obtained from the 24-h Holter ECG(hECG) were compared between 20 HD patients and 20 healthy control subjects.ResultsFourteen HD patients had tachycardia, bradycardia, and extra beats. Interval between two heartbeats, normal-to-normal (NN), standard deviation of all normal-to-normal (SDNN), square root of the mean of the sum of the squares of the differences between consecutive N-N intervals in ms (rMSSD), and the ratio of the number of consecutive pairs of N-N intervals that differ by more than 50 ms to the total number of N-N intervals (pNN50) were all significantly higher in the patient group than in the control group during 24-h hECG monitoring. However, hECG monitoring showed that the patient group had significantly higher values of the frequency-domain metrics high frequency (HF) than the control group did (P = 0.003). Very low frequency (VLF) was lower in the patient group (P = 0.009). There was no difference in low frequency (LF) in both groups. In comparison to the control group, LF/HF was much reduced in the patient group (P = 0.001).ConclusionCardiac disfunction increases, and autonomic functions change in HD, but more comprehensive studies are needed to distinguish sympathetic and parasympathetic involvement.
dc.description.sponsorshipNigde Omer Halisdemir University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s10072-024-07428-5
dc.identifier.endpage3828
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue8
dc.identifier.pmid38436789
dc.identifier.scopus2-s2.0-85186581842
dc.identifier.scopusqualityQ1
dc.identifier.startpage3823
dc.identifier.urihttps://doi.org/10.1007/s10072-024-07428-5
dc.identifier.urihttps://hdl.handle.net/11480/13991
dc.identifier.volume45
dc.identifier.wosWOS:001173470400002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlag Italia Srl
dc.relation.ispartofNeurological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectHuntington's disease
dc.subjectCardiac autonomic dysfunction
dc.subjectHeart rate variability
dc.titleCardiac autonomic involvement in Huntington's disease
dc.typeArticle

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