Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae

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dc.authoridKawano, Tomonori/0000-0002-6876-9399
dc.authoridMetin, Mert/0000-0003-3476-1089
dc.authoridGul, Alvina/0000-0002-7323-1905
dc.contributor.authorOzturk, Munir
dc.contributor.authorMetin, Mert
dc.contributor.authorAltay, Volkan
dc.contributor.authorDe Filippis, Luigi
dc.contributor.authorUnal, Bengu Turkyilmaz
dc.contributor.authorKhursheed, Anum
dc.contributor.authorGul, Alvina
dc.date.accessioned2024-11-07T13:35:26Z
dc.date.available2024-11-07T13:35:26Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractCadmium (Cd) is a toxic heavy metal mainly originating from industrial activities and causes environmental pollution. To better understand its toxicity and pollution remediation, we must understand the effects of Cd on living beings. Saccharomyces cerevisiae (budding yeast) is an eukaryotic unicellular model organism. It has provided much scientific knowledge about cellular and molecular biology in addition to its economic benefits. Effects associated with copper and zinc, sulfur and selenium metabolism, calcium (Ca2+) balance/signaling, and structure of phospholipids as a result of exposure to cadmium have been evaluated. In yeast as a result of cadmium stress, mitogen-activated protein kinase, high osmolarity glycerol, and cell wall integrity pathways have been reported to activate different signaling pathways. In addition, abnormalities and changes in protein structure, ribosomes, cell cycle disruption, and reactive oxygen species (ROS) following cadmium cytotoxicity have also been detailed. Moreover, the key OLE1 gene that encodes for delta-9 FA desaturase in relation to cadmium toxicity has been discussed in more detail. Keeping all these studies in mind, an attempt has been made to evaluate published cellular and molecular toxicity data related to Cd stress, and specifically published on S. cerevisiae.
dc.identifier.doi10.1007/s12011-021-02584-7
dc.identifier.endpage4846
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue12
dc.identifier.pmid33462792
dc.identifier.scopus2-s2.0-85100133387
dc.identifier.scopusqualityQ1
dc.identifier.startpage4832
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02584-7
dc.identifier.urihttps://hdl.handle.net/11480/16508
dc.identifier.volume199
dc.identifier.wosWOS:000608685600003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectCadmium
dc.subjectMolecular biology
dc.subjectSaccharomyces cerevisiae
dc.subjectToxicity
dc.titleMolecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae
dc.typeArticle

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