Solubilizing effect of the p-phosphonate calix[n]arenes towards poorly soluble drug molecules such as nifedipine, niclosamide and furosemide

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dc.authorid0000-0003-2904-160X
dc.contributor.authorBayrakci, Mevlut
dc.contributor.authorErtul, Seref
dc.contributor.authorYilmaz, Mustafa
dc.date.accessioned2019-08-01T13:38:39Z
dc.date.available2019-08-01T13:38:39Z
dc.date.issued2012
dc.departmentNiğde ÖHÜ
dc.description.abstractThis article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained results, it was observed that the solubility of drug molecules was significantly increased in the presence of calix[n]arene host molecules. The increase in solubility of drugs by the calix[n]arene was most probably due to inclusion complexation between drug molecules and cavities of the calixarene skeleton similar to drug:cyclodextrin complexes.
dc.description.sponsorshipS.U. Research Foundation [BAP: 10101016]
dc.description.sponsorshipThis study is part of the PhD Thesis of Mevlut Bayrakci and the authors gratefully would like to thank S.U. Research Foundation (BAP: 10101016) for financial support.
dc.identifier.doi10.1007/s10847-012-0135-7
dc.identifier.endpage423
dc.identifier.issn1388-3127
dc.identifier.issn1573-1111
dc.identifier.issue45383
dc.identifier.scopus2-s2.0-84864440406
dc.identifier.scopusqualityQ3
dc.identifier.startpage415
dc.identifier.urihttps://dx.doi.org/10.1007/s10847-012-0135-7
dc.identifier.urihttps://hdl.handle.net/11480/4516
dc.identifier.volume74
dc.identifier.wosWOS:000306946700043
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[0-Belirlenecek]
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCalixarene
dc.subjectDrug
dc.subjectNifedipine
dc.subjectNiclosamide
dc.subjectFurosemide
dc.titleSolubilizing effect of the p-phosphonate calix[n]arenes towards poorly soluble drug molecules such as nifedipine, niclosamide and furosemide
dc.typeArticle

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