An Investigation of Clock Gene Variations in Turkish Nannospalax Species

Basit Öğe Kaydı
dc.contributor.authorCivelek, I.
dc.contributor.authorKankilic, T.
dc.contributor.authorAkin, D. F.
dc.date.accessioned2024-11-07T13:24:25Z
dc.date.available2024-11-07T13:24:25Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBlind mole rats (Nannospalax) have become famous for their long lifespans and cancer resistance, but it is still unknown what causes them to be resistant to cancer. These animals may have a different melatonin synthesis mechanism from other creatures due to their lifestyle, which is estimated to be connected to their cancer resistance. In this study, gene variants in Clock genes Cry1, Cry2, Bmal1, Per1 and Per2, which are involved in the synthesis of melatonin in Nannospalax species living in Turkey were investigated and compared with the other organisms including Nannospalax galili, Mus musculus, Heterocephalus glaber, Rattus norvegicus, and Homo sapiens. In addition, it was investigated whether the detected variations have a pathogenic effect in humans. For this purpose, in vitro methods and some bioinformatics tools were employed in this DNA-based research. 29 variants in total; 11 in Per1, 7 in Per2, 2 in Cry1 and 9 in Cry2 gene, were identified, no variation was found in Bmal1 gene. Some of these variations have been found in regions where DNA repair processes for light-induced UV damage occurred. Other variations were detected in PAS domain and 5'-UTR regions, and the remaining variations were in nondomain regions of proteins. Since Clock gene variations has not been investigated in Nannospalax species, these in vitro and in silico methods may give suggestions to choose and focus on detected variations to be used for further studies.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [123Z007]; Nigde OEmer Halisdemir University [FMT 2022/7-BAGEP]
dc.description.sponsorshipThis article has been derived from a PhD thesis, yet to be presented to the University, titled Tuerkiye Nannospalax tuerlerinde (Nannospalax xanthodon, Nannospalax ehrenbergi, Nannospalax leucodon) Clock Gen (Per1, Per2, Cry1, Cry2, Bmal1) Varyasyonlar & imath;n & imath;n Ara & scedil;t & imath;r & imath;lmas & imath;. This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant 123Z007 and Nigde OEmer Halisdemir University under Grant FMT 2022/7-BAGEP.
dc.identifier.doi10.1134/S1022795424040057
dc.identifier.endpage639
dc.identifier.issn1022-7954
dc.identifier.issn1608-3369
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85194039355
dc.identifier.scopusqualityQ4
dc.identifier.startpage626
dc.identifier.urihttps://doi.org/10.1134/S1022795424040057
dc.identifier.urihttps://hdl.handle.net/11480/14097
dc.identifier.volume60
dc.identifier.wosWOS:001228904500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofRussian Journal of Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectNannospalax
dc.subjectblind mole rat
dc.subjectclock genes
dc.subjectvariation
dc.titleAn Investigation of Clock Gene Variations in Turkish Nannospalax Species
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu