The role of cervical elastography in the differential diagnosis of preinvasive and invasive lesions of the cervix

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dc.authoridCakir, Caner/0000-0003-2559-9104
dc.contributor.authorYucel, Ecem
dc.contributor.authorYildirim, Hande Esra Koca
dc.contributor.authorDuran, Firdevs Sahin
dc.contributor.authorCakir, Caner
dc.contributor.authorKorkmaz, Vakkas
dc.date.accessioned2024-11-07T13:31:31Z
dc.date.available2024-11-07T13:31:31Z
dc.date.issued2024
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractStudy objective This study aims to evaluate the role of cervical elastography in the differential diagnosis of preinvasive and invasive lesions of the cervix. Materials and methods A total of 95 women participated in this prospective study and were divided into the following groups: 19 healthy subjects (group 1) with normal cervicovaginal smear (CVS) and negative human papillomavirus test (HPV DNA), 19 women with normal cervical biopsy and normal final pathological result of cervical biopsy (group 2), 19 women with low-grade squamous intraepithelial lesion (LSIL) (group 3), 19 women with high-grade squamous intraepithelial lesion (HSIL) (group 4), and 19 women with cervical cancer (group 5). Clinical, demographic, histopathological, and elastographic results were compared between these groups. Results Comparing groups, age (40.42 +/- 8.31 vs. 39.53 +/- 8.96 vs. 38.79 +/- 9.53 vs. 40.74 +/- 7.42 vs. 54.63 +/- 12.93, p < 0.001 respectively), gravida (1.74 +/- 1.33 vs. 2.16 +/- 1.68 vs. 2.21 +/- 1.96 vs. 2.53 +/- 1.93 vs. 4.63 +/- 2.17 p < 0.001 respectively), parity (1.37 +/- 0.68 vs. 1.68 +/- 1.20 vs. 1.58 +/- 1.30 vs. 2.00 +/- 1.67 vs. 3.37 +/- 1.61, p < 0.001 respectively), and the proportion of patients at menopause (10.5% vs., 15.8% vs. 10.5% vs. 5.3% vs. 57.9%, p < 0.01 respectively), a statistically significant difference was found (Table 1). However, no statistically significant difference was found in the number of abortions, BMI, mode of delivery, smoking, additional disease status, history of surgery, and family history (p > 0.05) (Table 2. As a result of the applied roc analysis, mean cervical elastographic stiffness degree (ESD) was found to be an influential factor in predicting cervical cancer (p < 0.05). The mean cut-off value was 44.65%, with a sensitivity of 94.7% and a specificity of 96.1% (Table 7). Conclusion Measurement of ESD by elastography is a low-cost, easily applicable, and non-invasive indicator that can distinguish cervical cancer from normal cervical and preinvasive lesions. However, it is unsuitable for determining preinvasive cervical lesions from normal cervix.
dc.identifier.doi10.1007/s00404-023-07345-6
dc.identifier.endpage1595
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue4
dc.identifier.pmid38282023
dc.identifier.startpage1585
dc.identifier.urihttps://doi.org/10.1007/s00404-023-07345-6
dc.identifier.urihttps://hdl.handle.net/11480/14884
dc.identifier.volume309
dc.identifier.wosWOS:001151688800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectElastography
dc.subjectCervical cancer
dc.subjectTransvaginal ultrasound
dc.subjectHSIL
dc.subjectLSIL
dc.titleThe role of cervical elastography in the differential diagnosis of preinvasive and invasive lesions of the cervix
dc.typeArticle

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