Dietary N-carbamylglutamate or L-arginine supplementation improves hepatic energy status and mitochondrial function and inhibits the AMP-activated protein kinase- peroxisome proliferator-activated receptor ? coactivator-1?-transcription factor A pathway in intrauterine-growth-retarded suckling lambs

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dc.authoridElsabagh, Mabrouk/0000-0002-0596-6547
dc.authoridWang, Hongrong/0000-0002-4980-1082
dc.contributor.authorZhang, Hao
dc.contributor.authorLiu, Xiaoyun
dc.contributor.authorRen, Shengnan
dc.contributor.authorElsabagh, Mabrouk
dc.contributor.authorWang, Mengzhi
dc.contributor.authorWang, Hongrong
dc.date.accessioned2024-11-07T13:34:51Z
dc.date.available2024-11-07T13:34:51Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe objective of this study was to investigate the effects of dietary administration of L-arginine (Arg) or N-carbamylglutamate (NCG) on hepatic energy status and mitochondrial functions in suckling Hu lambs with intrauterine growth retardation (IUGR). Forty-eight newborn Hu lambs of 7 d old were allocated into 4 treatment groups of 12 lambs each, in triplicate with 4 lambs per replicate (2 males and 2 females) as follows: CON (lambs of normal birth weight, 4.25 +/- 0.14 kg), IUGR (3.01 +/- 0.12 kg), IUGR thorn 1% Arg (2.99 +/- 0.13 kg), or IUGR thorn 0.1% NCG (3.03 +/- 0.11 kg). The experiment lasted for 21 d, until d 28 after birth, and all lambs were fed milk replacer as a basal diet. Compared with IUGR lambs, NCG or Arg administration increased (P < 0.05) the adenosine triphosphate (ATP) level and the activities of complexes I/III/IV, isocitrate dehydrogenase and citrate synthase in the liver. Compared with CON lambs, the relative mRNA levels of adenosine monophosphate-activated protein kinase alpha 1 (AMPK alpha 1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1 alpha) and transcription factor A (TFAM) were increased (P < 0.05) in the liver of IUGR lambs, but were decreased (P < 0.05) in the liver of NCG- or Arg-treated lambs compared with those in the IUGR lambs. Compared with IUGR lambs, NCG or Arg administration decreased (P < 0.05) the total AMPK alpha (tAMPK alpha)-to-phosphorylated AMPK alpha (pAMPK alpha) ratio and the protein expression of PGC1a alpha and TFAM. The results suggested that dietary Arg or NCG supplements improved hepatic energy status and mitochondrial function and inhibited the AMPK-PGC1 alpha-TFAM pathway in IUGR suckling lambs. (C) 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
dc.description.sponsorshipfund for the National Natural Science Foundation of China [31902180]; Research Project of Natural Science Foundation of Jiangsu Province [BK20170488]; China Postdoctoral Science Foundation [2017M610358]; Science and Technology Innovation Project of Yangzhou University [2019CXJ152]; Top Talents Award Plan of Yangzhou University (2020); Cyanine Project of Yangzhou University (2020)
dc.description.sponsorshipThe research was supported by the fund for the National Natural Science Foundation of China (31902180), the Research Project of Natural Science Foundation of Jiangsu Province (BK20170488), the China Postdoctoral Science Foundation (2017M610358), the Science and Technology Innovation Project of Yangzhou University (2019CXJ152), the Top Talents Award Plan of Yangzhou University (2020), and the Cyanine Project of Yangzhou University (2020).
dc.identifier.doi10.1016/j.aninu.2021.02.005
dc.identifier.endpage867
dc.identifier.issn2405-6383
dc.identifier.issn2405-6545
dc.identifier.issue3
dc.identifier.pmid34466690
dc.identifier.scopus2-s2.0-85122709751
dc.identifier.scopusqualityQ1
dc.identifier.startpage859
dc.identifier.urihttps://doi.org/10.1016/j.aninu.2021.02.005
dc.identifier.urihttps://hdl.handle.net/11480/16210
dc.identifier.volume7
dc.identifier.wosWOS:000701712000026
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKeai Publishing Ltd
dc.relation.ispartofAnimal Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241106
dc.subjectL-Arginine
dc.subjectLiver
dc.subjectIntrauterine growth restriction
dc.subjectEnergy status
dc.subjectMitochondrial function
dc.subjectN-carbamylglutamate
dc.titleDietary N-carbamylglutamate or L-arginine supplementation improves hepatic energy status and mitochondrial function and inhibits the AMP-activated protein kinase- peroxisome proliferator-activated receptor ? coactivator-1?-transcription factor A pathway in intrauterine-growth-retarded suckling lambs
dc.typeArticle

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