Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach

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dc.authoridDurdagi, Serdar/0000-0002-0426-0905
dc.authoridEkhteiari Salmas, Ramin/0000-0003-3888-5070
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.contributor.authorSalmas, Ramin Ekhteiari
dc.contributor.authorGulhan, Mehmet Fuat
dc.contributor.authorDurdagi, Serdar
dc.contributor.authorSahna, Engin
dc.contributor.authorAbdullah, Huda I.
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-11-07T13:34:32Z
dc.date.available2024-11-07T13:34:32Z
dc.date.issued2017
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractThe objective of this study was to evaluate the antioxidant effects of propolis, caffeic acid phenethyl ester (CAPE; active compound in propolis), and pollen on biochemical oxidative stress biomarkers in rat kidney tissue inhibited by N-nitro-L-arginine methyl ester (L-NAME). The biomarkers evaluated were paraoxonase (PON1), oxidative stress index (OSI), total antioxidant status (TAS), total oxidant status (TOS), asymmetric dimethylarginine (ADMA), and nuclear factor kappa B (NF-B). TAS levels and PON1 activity were significantly decreased in kidney tissue samples in the L-NAME-treated group (P<0.05). The levels of TAS and PONI were higher in the L-NAME plus propolis, CAPE, and pollen groups compared with the L-NAME-treated group. TOS, ADMA, and NF-B levels were significantly increased in the kidney tissue samples of the L-NAME-treated group (P<0.05). However, these parameters were significantly lower in the L-NAME plus propolis, CAPE, and pollen groups (P<0.05) compared with rats administered L-NAME alone (P<0.05). Furthermore, the binding energy of CAPE within catalytic domain of glutathione reductase (GR) enzyme as well as its inhibitory mechanism was determined using molecular modeling approaches. In conclusion, experimental and theoretical data suggested that oxidative alterations occurring in the kidney tissue of chronic hypertensive rats may be prevented via active compound of propolis, CAPE administration.
dc.description.sponsorshipOmer Halisdemir University (Turkey) Research Fund [BAP 2012/38]
dc.description.sponsorshipOmer Halisdemir University (Turkey) Research Fund (Project number: BAP 2012/38) is gratefully acknowledged for support of this work.
dc.identifier.doi10.1002/cbf.3277
dc.identifier.endpage314
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6
dc.identifier.pmid28833317
dc.identifier.scopus2-s2.0-85028434459
dc.identifier.scopusqualityQ2
dc.identifier.startpage304
dc.identifier.urihttps://doi.org/10.1002/cbf.3277
dc.identifier.urihttps://hdl.handle.net/11480/16040
dc.identifier.volume35
dc.identifier.wosWOS:000408477400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofCell Biochemistry and Function
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectCAPE
dc.subjecthypertension
dc.subjectMM-PBSA
dc.subjectmolecular dynamics simulations
dc.subjectmolecular modeling
dc.subjectpollen
dc.subjectpropolis
dc.titleEffects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach
dc.typeArticle

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