Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways

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dc.authoridRiaz, Ammara/0000-0001-5025-9182
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridShah, Muhammad Ajmal/0000-0003-3471-184X
dc.contributor.authorKanwal, Nazia
dc.contributor.authorRasul, Azhar
dc.contributor.authorHussain, Ghulam
dc.contributor.authorAnwar, Haseeb
dc.contributor.authorShah, Muhammad Ajmal
dc.contributor.authorSarfraz, Iqra
dc.contributor.authorRiaz, Ammara
dc.date.accessioned2024-11-07T13:31:52Z
dc.date.available2024-11-07T13:31:52Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractNerium oleander, a member of family Apocynaceae, is commonly known as Kaner in various countries of Asia and Mediterranean region. This plant has been renowned to possess significant therapeutic potential due to its various bioactive compounds which have been isolated from this plant e.g., cardiac glycosides, oleandrin, a-tocopherol, digitoxingenin, umsolic acid, quercetin, odorosides, and adigoside. Oleandrin, a saponin glycoside is one of the most potent and pharmacologically active phytochemicals of N. oleander. Its remarkable pharmacotherapeutic potential have been interpreted as anticancer, anti-inflammatory, anti-HIV, neuropmtective, antimicrobial and antioxidant. This particular bioactive entity is known to target the multiple deregulated signaling cascades of cancer such as NF-kappa B, MAPK, and PI3K/Akt. The main focus of the current study is to comprehend the action mechanisms of oleandrin against various pathological conditions. The current review is a comprehensive summary to facilitate the researchers to understand the pharmacological position of the oleandrin in the arena of drug discovery, representing this compound as a new drug candidate for further researches. Moreover, in vivo and in silico based studies are required to explore the mechanistic approaches regarding the pharmacokinetics and biosafety profiling of this compound to completely track its candidature status in natural drug discovery.
dc.description.sponsorshipNRPU [8381/Punjab/NRPU/RD/HEC/2017, 8382/Punjab/NRPU/RD/HEC/2017]; Nagai Foundation Tokyo, Japan [NFT-R2018]; TWAS-COMSTECH Research Grant [17-180 RG/PHA/AS_C]
dc.description.sponsorshipThe author(s) have disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was completed under the support of research grants by NRPU Research Grants (8381/Punjab/NRPU/R&D/HEC/2017, 8382/Punjab/NRPU/R&D/HEC/2017), The Nagai Foundation Tokyo, Japan (NFT-R2018), and TWAS-COMSTECH Research Grant (No. 17-180 RG/PHA/AS_C).
dc.identifier.doi10.1016/j.fct.2020.111570
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid32640345
dc.identifier.scopus2-s2.0-85087755434
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fct.2020.111570
dc.identifier.urihttps://hdl.handle.net/11480/15084
dc.identifier.volume143
dc.identifier.wosWOS:000562731900041
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectOleandrin
dc.subjectNerium oleander
dc.subjectAnticancer
dc.subjectGlycoside
dc.titleOleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways
dc.typeArticle

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