Therapeutic effects of Lacosamide in a rat model of traumatic brain injury: A histological, biochemical and electroencephalography monitoring study

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dc.authoridOZEL, HASAN FEHMI/0000-0003-1676-0648
dc.authoridAYDEMIR, ISIL/0000-0002-4143-7319
dc.authoridCollu, Fatih/0000-0001-6978-8404
dc.authoridunsal, ulkun unlu/0000-0001-5194-3138
dc.contributor.authorMete, Mesut
dc.contributor.authorAlpay, Suheda
dc.contributor.authorAydemir, Isil
dc.contributor.authorUnsal, Ulkun Unlu
dc.contributor.authorCollu, Fatih
dc.contributor.authorOzel, Hasan Fehmi
dc.contributor.authorDuransoy, Yusuf Kurtulus
dc.date.accessioned2024-11-07T13:34:41Z
dc.date.available2024-11-07T13:34:41Z
dc.date.issued2021
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractObjective: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI can be classified based on severity, mechanism or other features. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophys-iological mechanisms underlying neuronal loss after TBI. Lacosamide (LCM) is an anticonvulsant compound approved for the adjunctive treatment of partial-onset seizures and neuropathic pain. This study aimed to investigate possible neuroprotective effects of LCM in a rat model of TBI. Material and methods: Twenty-eight adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the control group (n=7). Group 2 was the trauma group (n=7) where rats were treated with 100 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 6 (group 3, n=7) or 20 (group 4, n=7) mg/kg Lacosamide IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. In addition, electroencephalograpy monitoring results were compared. Results: The immunoreactivity of both iNOS and eNOS (oxidative stress markers) were decreased with LCM treatment compared to trauma group. The results were statistically significant (*** P<0.001). The treatments of low (56,17 +/- 9,69) and high-dose LCM (43,91 +/- 9,09) were decreased the distribution of HIF-1 alpha compared to trauma group (P<0.01). The number of apoptotic cells were decreased with LCM treatment the difference between the trauma group and 20mg/kg LCM treated group (9,55 +/- 1,02) was statistically significant (***P<0.001). Malondialdehyde level was reduced with LCM treatment. MDA level was significantly higher in trauma group compared to LCM treated groups (*** P<0.001). The level of Superoxide dismutase in the trauma group was 1,86 U/ml, whereas it was 36,85 U/ml in 20mg/kg LCM treated group (*** P<0.001). Delta strength of EEG in 20mg/kg LCM treated group were similar to control group values after LCM treatment. Conclusion: No existing study has produced results suggesting that different doses of LCM has therapeutic effect against TBI, using EEG recording in addition to histological and biochemical evaluations in rats. (C) 2021 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific Research Project of the Manisa Celal Bayar University, Turkey [2017196]
dc.description.sponsorshipThis work was supported by the Scientific Research Project of the Manisa Celal Bayar University, Turkey (Grant Number: 2017196) .
dc.identifier.doi10.1016/j.injury.2021.02.055
dc.identifier.endpage723
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.issue4
dc.identifier.pmid33714548
dc.identifier.scopus2-s2.0-85104699657
dc.identifier.scopusqualityQ1
dc.identifier.startpage713
dc.identifier.urihttps://doi.org/10.1016/j.injury.2021.02.055
dc.identifier.urihttps://hdl.handle.net/11480/16122
dc.identifier.volume52
dc.identifier.wosWOS:000643674700012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofInjury-International Journal of the Care of the Injured
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectElectroencephalography
dc.subjectLacosamide
dc.subjectNeuroprotective
dc.subjectTraumatic Brain Injury
dc.titleTherapeutic effects of Lacosamide in a rat model of traumatic brain injury: A histological, biochemical and electroencephalography monitoring study
dc.typeArticle

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