Determination of levels of oxidative stress and nitrosative stress in patients with epilepsy

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dc.contributor.authorErsan, Serpil
dc.contributor.authorCigdem, Burhanettin
dc.contributor.authorBakir, Deniz
dc.contributor.authorDogan, H. Okan
dc.date.accessioned2024-11-07T13:31:25Z
dc.date.available2024-11-07T13:31:25Z
dc.date.issued2020
dc.departmentNiğde Ömer Halisdemir Üniversitesi
dc.description.abstractBackground: Epilepsy is one of the most common neurological diseases. The underlying pathophysiological mechanisms in epilepsy are still unknown. Oxidative stress is believed to be one of the factors involved in the pathogenesis of epileptogenesis. In various pathophysiological conditions, reactive nitrogen species (RNS) such as nitrogen and peroxynitrite are produced and these RNSs can bind to free nucleosides and nucleotides or to nucleosides and nucleotides existing in the DNA/RNA structure. 8-Nitroguanine (8-NG) is a typical DNA nucleobase product of nitrosative damage generated by RNS. It has been proposed that F2-isoprostanes, in particular 8-iso-Prostaglandin F2a (8-isoPGF2a), are specific, reliable and non-invasive biomarkers of lipid peroxidation in vivo. In the present study, we compared the levels of lipid oxidative stress biomarker 8-isoPGF2a and nitrosative stress DNA biomarker 8-NG in patients with epilepsy undergoing antiepileptic drug (AEDs) treatment and with those in healthy participants. Methods: The present study comprised 90 patients aged between 17 and 53 who were admitted to the Neurology Clinic of Cumhuriyet University and diagnosed with epilepsy. The patients were assigned into the intervention (n = 45) and control (n = 45) groups. Of the participants in the intervention group, 37.7% (n = 17) were treated with levetiracetam (LEV), 33.3% (n = 15) with valproic acid (VA) and 29% (n = 13) with carbamazepine. Serum 8-iso-PGF2a and 8-NG levels of the participants in the intervention and control groups were determined by ELISA. Results: There was no significant difference between the medication (LEV, VA, Carbamazepine) used by the participants and their 8-iso-PGF2a and 8-NG levels (p> 0.05). However, 8-iso-PGF2a and 8-NG were significantly higher in the participants in the intervention than in the participants in the control group (p< 0.001). Conclusion: Our study demonstrated that there was an increase in oxidative and nitrosative stres markers in patients with epilepsy. There was no significant difference between the 8-iso-PGF2a and 8-NG levels of the participants taking three different AEDs.
dc.identifier.doi10.1016/j.eplepsyres.2020.106352
dc.identifier.issn0920-1211
dc.identifier.issn1872-6844
dc.identifier.pmid32446164
dc.identifier.scopus2-s2.0-85085498566
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2020.106352
dc.identifier.urihttps://hdl.handle.net/11480/14837
dc.identifier.volume164
dc.identifier.wosWOS:000539340300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEpilepsy Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241106
dc.subjectEpilepsy
dc.subjectOxidative stress
dc.subjectNitrosative stress
dc.subject8-isoProstaglandinF2 alpha
dc.subject8-Nitroguanine
dc.titleDetermination of levels of oxidative stress and nitrosative stress in patients with epilepsy
dc.typeArticle

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